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Images that show what is going on in crohn's disease.

The theory of autoimmunity in crohn's disease has been entirely discredited over the last decade, there is no self-antigen in crohn's disease, we find invasive E coli and fungi in places where there are granuloma and susceptibility genes are all related to both the recognition, and clearance (xenophagy) of bacteria and fungi. Autoimmune theory is dead.

A ton of studies have made schematics explaining how immunodefficiency, bacteria and fungi are involved in crohn's disease.

Just wanted to post some of them that do a good job showing what is going on in this disease.

(courtesy of R. Balfour Sartor and Tony Segal)

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