I just had a medrol injection and followed wih a dose pack while on LDN. My BP spiked for two days, but I don't know if that was from the combo or just the steroids. That was the first time I ever had a steroid injected. Otherwise seemed fine. I may need to go back on a steroid for a month or two if this flare doesn't stay under control. Doctor didn't seem to think it would be a problem.