Hi, I'm new to this forum and about to start Vedolizumab next Tuesday. I had a picc line put in yesterday due to poor vascular access. I've had bad reactions to previous infusions of infliximab and humira and wondered what to expect following this one. I work full time and I'm due to be in work the following day, or am I being too optimistic? Any advice or comments would be gratefully received, many thanks :smile: