Increases TGF-Beta signaling ,down regulates SMAD7.
Old Mike
http://medicalxpress.com/news/2015-03-drug-crohn-disease-early.html
much more
http://www.nejm.org/doi/pdf/10.1056/NEJMoa1407250
looks like they knew this stuff back in 01 and prior, took this long
http://www.jci.org/articles/view/12821
this is interesting SMAD7 increases with chronic dietary iron loading
food fortification comes to mind
http://asheducationbook.hematologylibrary.org/content/2011/1/532.full.pdf
Old Mike
http://medicalxpress.com/news/2015-03-drug-crohn-disease-early.html
much more
http://www.nejm.org/doi/pdf/10.1056/NEJMoa1407250
looks like they knew this stuff back in 01 and prior, took this long
http://www.jci.org/articles/view/12821
this is interesting SMAD7 increases with chronic dietary iron loading
food fortification comes to mind
http://asheducationbook.hematologylibrary.org/content/2011/1/532.full.pdf
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