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Recent content by David in Seattle

  1. David in Seattle

    Review Article: The Role of Non-biological Drugs in Refractory IBD

    Tioguanine. An active metabolite of azathioprine and MP, tioguanine, has been considered as an alternative therapy in patients who were intolerant of azathioprine or MP. In one study of 40 patients (10 with UC) with thiopurine-refractory disease, tioguanine 40 mg was given for a median of 34...
  2. David in Seattle

    Review Article: The Role of Non-biological Drugs in Refractory IBD

    S. C. Ng; F. K. L. Chan; J. J. Y. Sung Alimentary Pharmacology & Therapeutics. 2011;33(4):417-427. © 2011 Abstract and Introduction Abstract Background Up to one-third of patients with inflammatory bowel disease (IBD) do not respond to, or are intolerant of conventional immunosuppressive...
  3. David in Seattle

    Treatment of IBS: Beyond Fiber and Antispasmodic Agents

    Treatment of Irritable Bowel Syndrome Beyond Fiber and Antispasmodic Agents Anita Sainsbury, MBChB, MRCP, MD; Alexander C. Ford, MBchB, MRCP, MD Ther Adv Gastroenterol. 2011;4(2):115-127. © 2011 Sage Publications, Inc. Abstract and Introduction Irritable bowel syndrome (IBS) is a chronic...
  4. David in Seattle

    Were you delivered vaginally, or by Cesarean?

    Wendy - But first WHAT? "A word from our sponsors"????? LOL! Couldn't resist! BTW glad you made it :thumleft: Interesting poll results.
  5. David in Seattle

    Were you delivered vaginally, or by Cesarean?

    I recently read a study which seems to show a relationship between delivery by Cesarean section and bowel diseases, particularly Celiac disease. The authors theorize the relationship is based on the marked observed differences in gut flora seen in the 2 groups, and that there may also be a...
  6. David in Seattle

    Infants Delivered By Cesarean May Be More Likely to Develop Celiac Disease

    Pediatrics, 2010. Cesarean delivery is related to a higher incidence of pediatric celiac disease, according to an article published in Pediatrics. After birth, an infant's environment shifts from a sterile space to one colonized by bacteria. Almost immediately, microbial products and live...
  7. David in Seattle

    Antibiotic Therapy May Help in Inflammatory Bowel Disease

    Am J Gastroenterol 2011 Antibiotic therapy may induce remission in active ulcerative colitis and Crohn's disease, giving weight to the notion that inflammatory bowel disease (IBD) is of bacterial origin. But the researchers who drew this conclusion also said the data they pooled for a...
  8. David in Seattle

    Has anyone here taken "Iberogast"/"STW 5"?

    I am undiagnosed. I've been told "Crohn's", I've been told "IBS", most of us know the drill. Anyway, I recently read a study that showed the combination of herbal extracts contained in a product called "Iberogast", also known as "STW 5", was statistically superior to placebo in providing...
  9. David in Seattle

    Immunosuppressives Not Definitively Proven to Ease IBD

    Am J Gastroenterol 2011. There is some evidence that immunosuppressive drugs can help prevent relapse of inflammatory bowel disease (IBD), but it's not conclusive, a new meta-analysis shows. Immunosuppressives are favored by patients and doctors, but "many of the clinical trials are small, the...
  10. David in Seattle

    FDA Warns Again of Lymphoma Risk With TNF Blockers in Teens

    The US Food and Drug Administration (FDA) continues to receive reports of hepatosplenic T-cell lymphoma (HSTCL) in adolescents and young adults treated with tumor necrosis factor (TNF) blockers, azathioprine, and/or mercaptopurine, the agency said today. HSTCL has been reported in patients...
  11. David in Seattle

    "Baker" selling wheat bread as gluten free gets 9 - 11 years in jail

    Bogus baker gets prison term RALEIGH -- When Paul Seelig, the Durham "baker" who sold bogus gluten-free bread that sickened dozens of people, was sentenced to up to 11 years in prison in Wake Superior Court on Tuesday, a digital cheer erupted from the nation's celiac community. It wasn't just...
  12. David in Seattle

    Immunizing Patients With Gastrointestinal Diseases

    Conclusion: We Can Do Better In summary, who should receive live vaccines? Basically we can give live vaccines only to patients who are not immunocompromised. There are recent recommendations from a national consensus on vaccinations.[2] If the patient is on low-dose immunosuppressants -- and...
  13. David in Seattle

    Immunizing Patients With Gastrointestinal Diseases

    Transcript of a brief video presentation on the subject: "Hello. I'm Dr. David Johnson, Professor of Medicine and Chief of Gastroenterology at Eastern Virginia Medical School in Norfolk, Virginia. I wanted to chat with you today about vaccination strategies because I don't care whether you're...
  14. David in Seattle

    The Bacterial Pathogenesis and Treatment of Pouchitis

    Figure 1. An algorithm for the treatment of pouchitis. Reproduced with permission from Blackwell Publishing Ltd (McLaughlin et al. [2008b]). Figure 2. Potential mechanism of dysbiosis in pouchitis.
  15. David in Seattle

    The Bacterial Pathogenesis and Treatment of Pouchitis

    Table 1. Studies comparing the microbiota of UC pouchitis with nonpouchitis patient samples. UC, ulcerative colitis; FAP, familial adenomatous polyposis; RPC, restorative proctocolectomy with ileal pouch-anal anastomosis; PDAI, pouch disease activity index. Table 2. Studies comparing the...