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Recent content by JMC

  1. JMC

    IBD causes increased risk of death from circulatory and respiratory disease

    A surprising finding, I would be interested in the interpretation, proof of infection or side of effect of the medication used to treat it? https://www.ncbi.nlm.nih.gov/pubmed/27797922
  2. JMC

    Thetanix trial begins

    Interesting concept and treatment approach: Thetanix is a live biotherapeutic, a new class of regulated therapeutics using bacteria to treat or cure disease. http://www.stockmarketwire.com/article/5401585/4D-starts-dosing-for-Thetanix-trial.html
  3. JMC

    This is why FMT works and why the microbiome matters

    "Prof Kim Lewis and Dr Philip Strandwitz, from the antimicrobial discovery centre at Northeastern University in the US, commented: "It may seem surprising that a member of the human microbiota - the community of bacteria that inhabits the body - produces an antibiotic."...
  4. JMC

    The Economic and Health-related Impact of Crohn's Disease

    The Economic and Health-related Impact of Crohn's Disease in the United States: Evidence from a Nationally Representative Survey http://www.ncbi.nlm.nih.gov/pubmed/26974852 Surely, 593,000 to 780,000 people affected at a cost of nearly $3.5 Billion annually deserves greater funding for research!
  5. JMC

    AbbVie's new treatment for gouging Crohn's patients

    Abbvie, currently gouging an eye watering $14 Billion a year from Humira has just bought a new biologic therapy which currently is in stage 2 trials for the treatment of Crohn's disease...
  6. JMC

    The case for Crohn's being caused by Mycobacterial Infection

    This is a great explanation from Rod Chiodini about the history and evolving theories about the cause of Crohn's disease and why the evidence fits a Mycobacterial infection: http://www.curecrohnsdisease.com/thecause.php
  7. JMC

    The Science of Stress and How Our Emotions Affect Our Susceptibility to Burnout and Disease

    Interesting and accessible article explaining the connection between stress its impact on our immune system. What I find interesting is the connection between mental and physical health in some illnesses. Stress is often cited as a triggering factor for the development of Crohn's or the start...
  8. JMC

    VirScan - identifying every virus you have ever had

    Given there now seems to be very little dispute that there is an "environmental" element (read pathogenic bacteria or virus) as a factor in the development of Crohn's disease, a quick and simple test which can identify every virus you have ever been exposed to is an exciting development. Now we...
  9. JMC

    Researchers Find Missing Link Between the Brain and Immune System

    An interesting paper, I wonder what the implications will be for IBD? I think we are all aware that Crohn's can affect the function of your brain, whether it is stress, anxiety or fuzzy headed forgetfulness. Will these now be clearly linked to the immune system malfunctioning...
  10. JMC

    Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

    Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease I had my regular quarterly hospital check up today and the gastroenterologist I saw mentioned this paper as an exciting development: http://www.nejm.org/doi/full/10.1056/NEJMoa1407250 CONCLUSIONS We found that study...
  11. JMC

    Apple ResearchKit

    This looks very cool, Crohn's must be precisely the sort of disease that could be massively helped by collection of more data http://www.apple.com/researchkit/
  12. JMC

    FMT and the risk of weight gain

    Interesting story on the BBC news website about a woman who had a stool transplant from her obese daughter and subsequently suffered extreme weight gain: http://www.bbc.co.uk/news/health-31168511
  13. JMC

    New antibiotics discovered

    This is a very exciting development, especially for those who believe Crohn's is caused by a pathogen like MAP or AIEC. http://www.bbc.co.uk/news/health-30657486
  14. JMC

    Research into MAP as the cause of Crohn's

    I know there are a lot of people interested in whether MAP is the cause of Crohn's, so rather than having a separate thread for each new paper, I thought it might be useful to have a single discussion for cataloguing the research. I do not propose listing all of the historical papers as a short...
  15. JMC

    Infliximab modifies response to MAP infection

    Interesting new paper: Infliximab therapy increases the frequency of circulating CD16(+) monocytes and modifies macrophage cytokine response to bacterial infection
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