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Recent content by Pangolin

  1. Pangolin

    Vedolizumab Brings Endoscopic Remission in Some Patients With Crohn's Disease

    Ok I finally read the whole paper, and I really don't think it's that bad. First, consider the population of patients they're using: "We performed a phase 3b, open-label, single-group study of 101 patients with at least 3 months of active CD (a CD Activity Index [CDAI] score of 220–450, a...
  2. Pangolin

    Redhill's latest press release clearly shows their RHB104 phase 3 results.

    Right that's interesting. The most impressive results to me are the calprotectin results compared to placebo. Very clear effect there and nothing funny going on with the placebo group. (And note that the placebo group here is also receiving other medications like anti-TNFs, etc)
  3. Pangolin

    Redhill's latest press release clearly shows their RHB104 phase 3 results.

    For such a difficult to treat condition and with patients already on various drugs, these are decent results. I think biologics like Remicade and Humira would show similar results if you tested them like this, but this may work better in some subset of patients.
  4. Pangolin

    Oral Vancomycin study

    They were all on other medications, but most kids in the study did not have additional medications added at the time of the vancomycin that could have explained the results. The improvements in pain, diarrhea, anemia, and blood in stool are large enough that they can't be explained by the other...
  5. Pangolin

    Oral Vancomycin study

    Anyone tried this? Due to the lack of absorption, this seems like it might be a safe option. Check out the graphs in the study--impressive reduction of pain, blood, and anemia. https://academic.oup.com/crohnscolitis360/article/1/2/otz015/5532749 Objective To study the efficacy of oral...
  6. Pangolin

    Bacteriophage therapy targeting adherent invasive ecoli

    https://academic.oup.com/ecco-jcc/article/11/7/840/2895107 Background and Aims: Adherent invasive Escherichia coli [AIEC] are abnormally predominant on the ileal mucosa of Crohn’s disease [CD] patients. They bind to the CEACAM6 receptor expressed on the surface of epithelial cells. We aimed to...
  7. Pangolin

    Perianal Crohn's: keeping an eye on the anus

    This might seem a little weird at first, but consider that in a case of Crohn's with perianal involvement, your most current and objective data on how things are going is a visual inspection. There is no better way to tell what the current level of inflammation in that region is than taking a...
  8. Pangolin

    Fecal transplants result in flares in crohn's disease, study stopped.

    I would take any claims of an association between higher microbiome diversity and better health with a grain of salt. I've also seen studies that indicate the opposite. It's just totally unknown, imo.
  9. Pangolin

    Fecal transplants result in flares in crohn's disease, study stopped.

    I don't think it's clear whether more or less diversity is in fact a good thing.
  10. Pangolin

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    I've noticed clustering in my own neighborhood (and family), enough to be concerned, eg, meeting a group of 20 people containing 4 people with Crohn's disease. Thinking back to your earlier comment on "organic" food and a very bad experience I had once after eating inadequately washed veggies...
  11. Pangolin

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Just a thought, but why don't milkmaids get smallpox? Because they've been infected with cowpox, of course. Perhaps the version common in cattle (which, as you note, presents differently from Crohn's) is different from the version common in humans and confers mild immunity to farmers.
  12. Pangolin

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Enbrel had a much stronger relationship with developing Crohn's, but the others might also have some increased risk (1.3 and 1.2 odds ratio). We might say that there's strong evidence that the anti-TNFs aren't preventing Crohn's disease, at least: "Korzenik and colleagues found that patients...
  13. Pangolin

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Anti-TNF agents linked to increased risk of IBD. https://www.medscape.com/viewarticle/915613
  14. Pangolin

    Heard from Doc today

    We could look at the study to find out the range of levels they had, but there's a good chance some patients had levels closer to 20. In order to make the averages nearly even, any in remission at higher levels were balanced out by those not in remission at higher levels and by those in...
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