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Recent content by Pangolin

  1. Pangolin

    Bowel inflammation when I take steroids, is it Crohn?

    That doesn't sound like Crohn's, but it does sound like a very bad reaction to prednisone. Maybe with more investigation you could figure out what the problem with your ears is and find something other than steroids that would improve them?
  2. Pangolin

    Intestinal barrier healing is superior to endoscopic and histologic remission for predicting major adverse outcomes in IBD: the prospective ERIca tria

    Wow, a new target. I think this is going to help people figure out if they're getting closer to true remission or not, and it may help get us closer to identifying causes.
  3. Pangolin

    VEO CROHN'S DISEASE

    ESR should really be below 10 in healthy children, and most often the results are 1 to 4 in healthy kids. When things were not under control for my son, his ESR was 15 to 30+, and now it's about 2. 18 is a positive signal for inflammation.
  4. Pangolin

    VEO CROHN'S DISEASE

    That ESR is rather concerning to me.
  5. Pangolin

    Switching from humira to stelera

    There can be a spike of inflammation (higher than your baseline Crohn's) after stopping biologics as your immune system goes back to normal function and either has some buildup of things to deal with or simply overshoots. I've seen it last for a couple of weeks. Stelara can start taking effect...
  6. Pangolin

    IUS

    Some other points: Regarding #2/5, keep in mind that biologics have a substantial rate of no longer working as time goes on. This should always be kept in mind when considering the retrial statistics--there's, for example, a 30% chance that it wouldn't have been working at the time of the...
  7. Pangolin

    IUS

    You don't need to just take my word for it (although of course you should). The most important parts of this have been tested: https://pubmed.ncbi.nlm.nih.gov/35390140/ Children who switched to stelara after skin reactions had better ourcomes.
  8. Pangolin

    IUS

    Stelara is just as effective as Humira at keeping Crohn's inflammation down, and it has the benefit of being substantially safer. If you're already dealing with a bad side effect from the Humira, I don't see why you wouldn't want to try Stelara instead. Most people are able to restart Humira if...
  9. Pangolin

    P.Anca positive blood test (UC or Crohn's Disease) ?

    Remicade can cause a positive anca and autoimmune problems, eg: https://pubmed.ncbi.nlm.nih.gov/23265134/
  10. Pangolin

    VEO CROHN'S DISEASE

    Dr. Borody is an advocate of the MAP theory, and he's published some papers describing some very good results he's had with Crohn's patients, including in kids. That said, personally I think MAP is only a minor part of the whole picture of Crohn's causation, and I would recommend keeping an...
  11. Pangolin

    [Paywall] Escherichia coli bacteria associated with Crohn’s disease persist within phagolysosomes

    One problem with that is that some causes aren't necessarily reversible. Take the mouse model of Crohn's with DSS. The mice are given DSS, and they get intestinal inflammation, but stopping the DSS doesn't stop the inflammation. Once the damage is there, other things need to be done to stop the...
  12. Pangolin

    IUS

    One easy solution everyone should know about for needle pain: Get some 4% lidocaine cream, available otc at any drug store. Apply a dollop and cover with plastic wrap at least 30 minutes and preferably 1-2 hours before the needle. Wipe off and do the needle as normal. The area should be totally...
  13. Pangolin

    VEO CROHN'S DISEASE

    Borody is world class and has great research going on. Well worth checking out.
  14. Pangolin

    VEO CROHN'S DISEASE

    Oh, since you're in Australia you should really try to get into the Centre for Digestive Diseases to see if they can help: https://centrefordigestivediseases.com/
  15. Pangolin

    VEO CROHN'S DISEASE

    Sounds awful. I would be worried about azathioprine in a young boy due to cancer risk. Have the doctors discussed trying remicade, humira, or stelara? Are they quite sure it's Crohn's and not something else, possibly some infection? Antibiotics can be helpful sometimes for Crohn's, too. One of...
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