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  1. M

    Making SCD yogurt using lactose free milk and can I use starter from Trader Joe’s organic yogurt?

    Has anyone made it with lactose free milk? Are there potential problems with it? I looks like ALL the yogurt from Trader Joe’s contains bifidus which according to Breaking the Vicious Cycle is illegal. What to do? Does it really matter?
  2. M

    New vaccine possibility (not MAP)

    My son’s symptoms first showed up in the mouth. But we didn’t know what it was and he lived with a misdiagnosis and worsening condition for nearly a year. Turns out his mouth was a reflection of his entire digestive tract, and culminated in anal fistula formation. But, more inflammation and...
  3. M

    New vaccine possibility (not MAP)

    Kiny, the formation of granulomas makes sense and it would seem to clearly indicate an infection by a pathogen. But what about the people who don’t have granulomas? Can we still say the same thing? Thanks!
  4. M

    New vaccine possibility (not MAP)

    I understood that it was at times when the immune system is weakened, by stress or a bad cold, etc., and with older people whose immune system is no longer as robust. However I just read yesterday about the cattle vaccine being created at Washington State showing that in MAP, like in TB in...
  5. M

    Mapping the gut

    Something to keep an eye on...
  6. M

    New vaccine possibility (not MAP)

    Yesterday I learned of a very interesting company called Inflammatix. They have created several diagnostic tests using the host immune response to read the Immune system and diagnose specific diseases like sepsis, TB, etc. They can differentiate between viruses and bacteria, and latent and...
  7. M

    New vaccine possibility (not MAP)

    What I find difficult to understand is that although cases are growing in the under 10 age group, the majority of cases don’t appear until late adolescence and early adulthood. If the innate immune system is faulty, why does it take 20 or so years for Crohn’s to appear? The answer to this...
  8. M

    New vaccine possibility (not MAP)

    Perhaps CRISPR will be able to eventually “fix” the innate deficiencies?
  9. M

    Poor clearance of pathogens within macrophages.

    Kiny, so this is what confuses me about the feasibility of any vaccine: if the problem is from a genetic mutation that deals with the innate immune system, specifically the clearance of pathogens from macrophages how would a vaccine help? Vaccines target different T-cells. These are already...
  10. M

    Poor clearance of pathogens within macrophages.

    Challenging article, but interesting nevertheless (after a few reads! 😉)... It discusses the mechanism whereby macrophages fail to clear pathogens within their walls. This sentence stood out: “LACC1 genetic variants are associated with inflammatory bowel disease (IBD) (Jostins et al., 2012)...
  11. M

    Redhill's latest press release clearly shows their RHB104 phase 3 results.

    They must do a second phase 3 study which they have said will be much shorter than the last one. The cost of treatment should be a lot lower than biologics.
  12. M

    The dangers using the wrong antibiotics that are ineffective against AIEC.

    Ah! I like this! You are making me think! I totally get your concern and have thought the same. A few answers that I can provide: many people are tested for MAP BUT with tests that are not validated so none of those tests will be considered acceptable evidence by the scientific community...
  13. M

    The dangers using the wrong antibiotics that are ineffective against AIEC.

    Kiny, thank you for posting lots of good articles. I wish this last one at the beginning of the article hadn’t mentioned the Selby trial as failing to show that MAP is the culprit. I feel compelled to post Marcel Behr’s reanalysis of that study...
  14. M

    Redhill's latest press release clearly shows their RHB104 phase 3 results.

    Did you see the last couple of graphs? They compare AMAT (essentially RHB104) to Remicade and Humira. Borody will initially use Humira and then start the antibiotics. He’s had good results doing it that way.
  15. M

    Redhill's latest press release clearly shows their RHB104 phase 3 results.

    Hard to understand people's reluctance to consider this treatment. Please see page 22-34 for relevant info: https://ir.redhillbio.com/static-files/f465e5e9-5f4d-4f71-9584-b7958715e8d5?fbclid=IwAR2upo2HGLH-hrwNJBgJEKmpBvOShD7sppnGWgOHN9tKLQ0kMJVApcwzO0A
  16. M

    Fecal transplants result in flares in crohn's disease, study stopped.

    Mark Davis from Stanford has a project (pending funding) to determine what exactly the T-cells are targeting in Crohn’s. Do you think his results will mostly show AIEC, maybe with scattered MAP, fungus, etc. here and there? I should think it would be a huge help in figuring out what the cause...
  17. M

    Fecal transplants result in flares in crohn's disease, study stopped.

    Does AIEC cause fistula and fissures? When my son was initially diagnosed he was tested for e-coli but it came up negative...
  18. M

    What is inside the fecal stream that is driving inflammation.

    Interesting but these studies are old. Have none of these avenues been followed since these findings were published? I had understood that there were as yet no identified antigens in Crohn’s, hence the constant speculation of different causes. And if the bug(s) is larger than 22n-m then why...
  19. M

    Fecal transplants result in flares in crohn's disease, study stopped.

    Regarding finding AIEC and not MAP in granulomas, from what I understand it is extremely difficult to detect and that’s why there is so much controversy. But there is a UK company: PBD Biotech that has created a test using bacteriophages to detect viable MAP. It is in the midst of testing TB...
  20. M

    Fecal transplants result in flares in crohn's disease, study stopped.

    I like your last sentence! I am super intrigued by the potential of bacteriophages for Crohn’s! If it is AIEC how do people become infected? Why are cases growing in Asia and South America? It must be in the food, hence why MAP seems plausible via increased dairy consumption. Is it possible that...
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