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  1. M

    Odd finding in old clinical crohns trial

    Seems very very odd to me. Greens provoked inflammation after remission. Perhaps fiber getting trapped and increasing bacterial load. oldmike https://gut.bmj.com/content/gutjnl/32/6/702.full.pdf
  2. M

    How Mycobacterium tuberculosis escapes death in macrophages

    This is interesting, came out today on medical express. If MAP is a cause of crohn's, and if it works the same was as TB then nicotinamide may help. Old Mike https://medicalxpress.com/news/2018-07-mycobacterium-tuberculosis-death-macrophages.html
  3. M

    Body knows best: A natural healing mechanism for inflammatory bowel disease

    This is easy to do if it works in humans,at least for UC. You can get both supplements. You can get the full paper by going down to more info. I have been looking into iNOS/ Nitric Oxide for years, this approach looks to have merit. In a nut shell, upregulate in mucosa cells, but not so much in...
  4. M

    MAP and Arthritis

    Chicken and the egg or not. Old Mike https://medicalxpress.com/news/2018-01-bacteria-linked-rheumatoid-arthritis.html
  5. M

    Microbial dysbiosis in spouses of ulcerative colitis patients: Any clues to disease pathogenesis?

    Wonderful: Old Mike https://www.ncbi.nlm.nih.gov/pubmed/29085220
  6. M

    An Endogenous Nanomineral Chaperones Luminal Antigen and Peptidoglycan to Intestinal Immune Cells

    There is something going on with endogenous calcium,phosphate,and magnesium secreated in the small intestine and the immune system. They form nano particles which grab antigens and present to immune cells. Now what happens if magnesium deficient,perhaps some malfunction, wild guess. Then there...
  7. M

    Paleolithic Ketogenic diet crohn's remission N=1

    Not sure if this one was ever posted. Basically only meat diet. So was it ketosis or elimination of just about everything else. Old Mike http://www.ijcasereportsandimages.com/archive/2016/009-2016-ijcri/CR-10690-09-2016-toth/ijcri-1069009201690-toth-full-text.php
  8. M

    Dietary Creatine as a Possible Novel Treatment for Crohn’s Ileitis

    Dietary Creatine as a Possible Novel Treatment for Crohn’s Ileitis Here is something new and different. Caution too much can cause dehydration, or other adverse effects. Old Mike full paper N=1 but there now is a clinical trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5171926/
  9. M

    Team identifies fungus in humans for first time as key factor in Crohn's disease

    FYI. Hot off the press. Of course a question what came first the biofilm or the disease. Old Mike http://medicalxpress.com/news/2016-09-team-fungus-humans-key-factor.html
  10. M

    Another genetic variant for Crohn's

    FYI for what it's worth. Old Mike http://www.upmc.com/media/NewsReleases/2016/Pages/duerr-crohnsmicrobiome-gastro.aspx
  11. M

    Research Collaboration Identifies Serum Biomarkers that Predict Pre-Clinical IBD Development and Complications

    Quite interesting. About time. This was also know at least 10 years ago. Old Mike http://www.mountsinai.org/about-us/newsroom/press-releases/research-collaboration-identifies-serum-biomarkers-that-predict-pre-clinical-ibd-development-and-complications
  12. M

    My crazy theory as to why UC starts in the rectum.

    Based on my history. UC 1980,quit smoking in 1977. Prior history none. Now back in 1971 Nov-Dec, a good case of Korean craps,resulting in D for about 2 weeks. One day with the burning D, I felt something tear and a burning sensation for about 3 days, went away and did not think about it...
  13. M

    Curcumin may help overcome drug-resistant tuberculosis

    Here we go, if Curcumin acts the same way on MAP as TB we might have something,increases autophagy and apoptosis. Old Mike http://medicalxpress.com/news/2016-03-curcumin-drug-resistant-tuberculosis.html Abstract Background and objective With the worldwide emergence of highly...
  14. M

    Nutritional Immunity -MAP

    Since I have been researching IBD for about the last 36 years I am sort of running out of stuff to look at. Whether MAP is causal or a bystander in Crohn's don't know,but here is a somewhat different research path to look at. Will actually tie in with my iron thread. One aspect of nutritional...
  15. M

    Receiving antibiotics during delivery affects infant gut bacteria

    Oh boy, this can't be good. Are you set up for IBD before you are born,in some cases. Old Mike https://www.med.ualberta.ca/departments/pediatrics/news/2015/november/receiving-antibiotics-during-delivery-affects-infant-gut-bacteria
  16. M

    Here is why biologics may fail

    New info. MMP's can be activated by ROS/peroxides. MMP's deactivate biologics. Old Mike http://www.ncbi.nlm.nih.gov/pubmed/26170138
  17. M

    Best IBD microbiome/metabolic study I have ever found

    Not sure if ever posted before. Found it in an odd way, searching riboflavin and mucin. Highly complex, but you can now see a lot of what is going on in our guts. Its just not dysbiosis, the bugs are defending themselves from oxidative stress, and eating more mucus. Old Mike...
  18. M

    Primary manifestation of Inflammatory Bowel Disease (IBD) following subcutaneous autovaccination.

    Its a holy crap, what is going on here. I can guess none of us have done this. But what happens prior to IBD if say you have a bleeding hemi. Or just a hard stool that scrapes off the mucus layer, and you bleed and the immune system can sample all the bacteria in the stool,or is this person a...
  19. M

    Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence

    FYI: Something new just popped up, difficult read. Old Mike http://gut.bmj.com/content/early/2015/04/16/gutjnl-2015-309333.full.pdf+html
  20. M

    New drug for Crohn's disease shows early promise

    Increases TGF-Beta signaling ,down regulates SMAD7. Old Mike http://medicalxpress.com/news/2015-03-drug-crohn-disease-early.html much more http://www.nejm.org/doi/pdf/10.1056/NEJMoa1407250 looks like they knew this stuff back in 01 and prior, took this long...