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  1. xeridea

    Mechanistic Insights Into CD Pathogenesis

    A disturbance in mitochondrial function implicated in pathogenesis of Crohn's, and the bacteria Atopobium parvulum identified as a central player. This paper, published in Nature, delves into the role of dysbiosis in Crohn's. The authors studied the interaction of the microbiota with the host...
  2. xeridea

    SCD in Pediatric CD Shows 80% Response

    Dr. Suskind et. al. of Seattle Children's have published a 12 week study on SCD for PCD. There was no control group, but 80% of the participants showed clinical remission by end of study period. What is nice with this study is they have results showing normalization of PCDAI, ESR, CRP, to an...
  3. xeridea

    Bonus: AIDS Drug has IBD benefits

    ABIVAX, a French company, is progressing nicely on their clinical trials of ABX464, a small molecule drug that inhibits the replication of HIV. The medicine targets the gut, which is the major reservoir of HIV in the body. This is being developed as a "functional cure" to prevent rebound of the...
  4. xeridea

    Lymphangitis cause of Crohn's Disease?

    I'm summarizing some papers I recently read. It talks about new observations of a possible cause that was first hypothesized many decades ago. Immunologist at Washington University St. Louis [1] are looking at possibility that something going awry in the intestinal lymphatic system may underlie...
  5. xeridea

    Caltech ATG16L1 T-Reg Discovery

    Caltech researchers have discovered that a mutation related to the ATG16L1 gene may prevent the body from throwing the "Off" switch. So rather than commensal bacteria activating an immune response, this is saying that beneficial bacteria cannot turn off the immune response. The researchers...
  6. xeridea

    Rare Autoinflammatory Disease Cause Found

    Researchers have discovered the cause of a rare immune disease, which they've newly named PAAND, that is similar to but uniquely distinct from Familial Mediterranean Fever. What makes this stand out is that they identified the gene mutation, the exact biochemistry that leads to the...
  7. xeridea

    Common genetic thread found

    Poring over genetic information from more than 86,000 people of European ancestry (50,000+ subjects, 35,000+ controls), researchers have discovered that five inflammatory diseases, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriasis, and primary sclerosing cholangitis, share a...
  8. xeridea

    Knockout target against UC discovered

    In a yet to be published study ("A protein truncating R179X variant in RNF186 confers protection against ulcerative colitis"), researchers have discovered a gene mutation that is protective against UC. If it passes review, this discovery will allow development of drugs that can knock out this...
  9. xeridea

    Humira improves microbiota

    In this small (n=16) study, it was shown that Treatment with Adalimumab Induces Changes in the Microbiota of Crohn’s Disease within 3 months. Below are result summary, T0 represents baseline, T3 3rd month at end of study. Results: T0 and T3 fingerprints were different in all patients; whereas T1...
  10. xeridea

    Shaman Medicine Being Studied by West

    This story starts off about a guy with Crohn's who after 10 years' of surgeries and conventional treatment opted to go down to the Amazon and be treated by a Shaman, with some remarkable results. The story is really about collaboration of researchers from the West setting up clinics to work...
  11. xeridea

    Anyone from Deerfield, IL

    There's a MAP symposium on Sunday August 16 at 2:00 pm at the BJBE Temple in Deerfield. Some of the leading MAP researchers will be speaking there. It'd be appreciated if a forum member can attend and report back. More info here: http://thecrohnsinfection.org/symposium-information/
  12. xeridea

    Using CRISPR/Cas9 to edit T-Cells

    This is somewhat bleeding-edge technology and has no immediate value for CD patients, but holds great promise as possible future therapy. Researchers at UC San Fransisco have been able to modify mature human CD4 T-Cells using CRISPR/CAS9 gene editing techniques. Since CD4 cytokines are...
  13. xeridea

    Bacteriophage targeting AIEC being brought to trial

    Ferring Pharmaceuticals is moving forward with development of a bacteriophage (viruses that infect bacteria) specifically targeting adherent invasive Escherichia coli (AIEC). Together with the Institut Pasteur and Intralytix, Ferring has developed a combination of bacteriophages specifically...
  14. xeridea

    Gut Reboot: Engineered Bacteria

    Recently funded DARPA initiative at Harvard's Wyss Institute aims to engineer E. Coli that can monitor gut health. These bacteria can detect things such as presence of harmful bacteria or gut inflammation, at which point the engineered bacteria change color, and when excreted, also change...
  15. xeridea

    Anyone Heard of Celastrol?

    A study was recently published on Celastrol (extract of Thunder God Vine) as possible treatment for obesity. It looks like the compound also has some very powerful anti-inflammatory characteristics, by way of its interactions with NF-kB and TNF-alpha. I found only one paper from a decade ago...
  16. xeridea

    Acupuncture/Moxibustion Study

    I've heard a lot of anecdotal accounts of acupuncture helping reduce some Crohn's symptoms. Here is a placebo-controlled study that delves into the mechanism of action which they propose is promotion of balance between the Th17 inflammatory and the Treg anti-inflammatory cells. The study...
  17. xeridea

    CCFA IBD Plexus Initiative

    CCFA Launches Development of World’s Largest Research Database for Crohn’s Disease and Ulcerative Colitis: First Ever Multi-Dimensional Knowledge Platform to Integrate Scientific, Medical and Patient Data More than 40,000 patients to participate $17.5 million lead funding committed by Helmsley...
  18. xeridea

    Tissue-Engineered Small Intestine

    Researchers have successfully engineered replacement intestinal segments that have digestive and absorptive functionality. Quoting from this article: We demonstrated that both mouse and human tissue-engineered small intestine grew into an appropriately polarized sphere of intact epithelium...
  19. xeridea

    Growing Guts in a Dish -- Research

    You gotta love science -- growing intestinal organoids as a study platform. University of Michigan scientists are embarking on a new program that grows human intestinal organoids from stem cells that they are coaxed into becoming a "guts in a dish". These are BB-sized balls comprised of the...
  20. xeridea

    Vitamin D Study

    Here's a nice retrospective study looking at the role of Vitamin D in Crohn's. Some points they touch on: Relationship of Vitamin D Serum Level and Disease Activity Role of Vitamin D in Innate Immune System Role of Vitamin D in Immune Regulation Genetic polymorphisms affecting Vitamin D Cites...
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