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  1. Pangolin

    Food antigen-induced immune responses in Crohn’s disease patients and experimental colitis

    In my son's experience, Pediasure with fiber was equally as effective as Pediasure without fiber, and both were not quite as effective as Pediasure Peptide.
  2. Pangolin

    Food antigen-induced immune responses in Crohn’s disease patients and experimental colitis

    Notice also that with a damaged gut and an immune response to many foods, it shouldn't be a surprise that it would result in inflammation, which might prevent the gut barrier from healing. So EEN can help by reducing the antigen content of food, including the bacterial content, resulting in...
  3. Pangolin

    Food antigen-induced immune responses in Crohn’s disease patients and experimental colitis

    The big thing I see here is that Crohn's patients are having immune responses to *many* foods. This could mean two things: 1. Crohn's patients' immune systems are *responding* much more to everything, and/or 2. Crohn's patients' immune systems are *exposed* much more to everything #1 doesn't...
  4. Pangolin

    Can't turn around a flare - advice

    The elemental or semi-elemental EEN suggestion is a good one. We noticed a substantial improvement when we switched from polymeric to semi-elemental formula.
  5. Pangolin

    Can't turn around a flare - advice

    This sounds familiar. My son was on EEN for a really long time because every time we tried food the symptoms got a lot worse. We tried Remicade and Entyvio, and inflammation persisted despite those plus EEN. Eventually he had a resection of the terminal ileum and got on Stelara, and things are...
  6. Pangolin

    My medicine is not working so I am looking into diets

    The really serious but effective dietary intervention is Exclusive Enteral Nutrition (EEN)--an all-formula diet. It's commonly used for kids but can also work for adults. Regarding medications, you may want to look into biologics such as Stelara.
  7. Pangolin

    The multifaceted virulence of adherent-invasive Escherichia coli

    One thing about Crohn's that I think is pretty clear but not well understood is the idea of downstream effects. I'm pretty sure that somehow areas of inflammation in the small intestine often cause inflammation in the large intestine, because one thing that's been observed is that small...
  8. Pangolin

    New to Crohns question

    I have noticed a positive correlation between inflammation and abdominal bloating, given equal food intake. This is one of many indicators you may begin to notice of how sick or healthy he is. Obviously eating more also takes up more space in there, too. I think there's a good chance MRI will...
  9. Pangolin

    Concerned Mom, looking for advice

    I don't really have any suggestions on nausea or what the cause might be, but odds are good that this isn't Crohn's. Classic Crohn's symptoms would include abdominal pain and diarrhea 3+ times per day persisting for a long time, and labs would usually show low hemoglobin and signs of...
  10. Pangolin

    High Calprotectin - On Remicade

    No reactions though, that's great so far. I think your son is only the first or second person I've seen on here starting Skyrizi, so I guess it's too early to see any trends from patient reports.
  11. Pangolin

    Trying to Conceive with Crohns flare up

    Technically he was told he could have a normal diet almost immediately after surgery, but we quickly discovered independently that EEN really helped at that time. I think it was a mistake for that not to be recommended by the doctors. The exact timeline was something like: EEN for about 6 weeks...
  12. Pangolin

    Trying to Conceive with Crohns flare up

    Ok here's my son's experience with surgery: He had a stricture at the end of his small intestine. It was there for years, and the biologics weren't able to touch it--if anything, it was slowly getting worse. So he had a surgery and had that short section of intestine removed, something like 6...
  13. Pangolin

    Trying to Conceive with Crohns flare up

    In general you want to preserve as much intestine as possible, and surgery after surgery removing more and more is definitely a problem. However, some people have a small region that's just not responding to any medicine, and there's just nothing that can be done about it except to take it out...
  14. Pangolin

    Trying to Conceive with Crohns flare up

    Some people say their Crohn's gets better when pregnant, and others say it gets worse. Active Crohn's would surely make pregnancy riskier, but some people do it. Maybe you could find a way to quickly get the Crohn's more under control? If none of those medicines are working, you still have some...
  15. Pangolin

    Recently diagnosed with Crohn's

    That shivering is probably due to a fever coming on, perhaps due to the Crohn's or an infection related to the Crohn's. You're kind of already maximizing biological therapy with Stelara ever 4 weeks, but there are some other things you could add on: EEN would make things easier on the inflamed...
  16. Pangolin

    Human IL-23 is essential for IFN-γ–dependent immunity to mycobacteria

    Another possibility is that the body is responding to mycobacteria but that response is excessive or unnecessary. Perhaps people are fine without that immune response and the mycobacteria doesn't spread, but maybe eliminating the mycobacteria (which may not be possible) could also prevent the...
  17. Pangolin

    Current and future aspects of IBD research and treatment: The 2022 perspective

    There is hope of durable remission if patients can reach the right targets, and the knowledge about what the right targets are is improving. I can't find the old study right now, but there was a promising one in which all of the patients who were on infliximab who had both mucosal healing and...
  18. Pangolin

    Current and future aspects of IBD research and treatment: The 2022 perspective

    I think that defining remission--even "deep" remission--is a huge problem for many of these studies, and that's what may have been going on in some of those infliximab studies. The thing is, mucosal healing is only part of the picture--in particular, there's also transmural healing. It's also...
  19. Pangolin

    High Calprotectin - On Remicade

    Oddly enough, my son just had a colonoscopy, too. He had perianal disease in addition to severe disease at the ileum, and neither Remicade nor Entyvio worked well. He had an ileocecal resection, and then even after that surgery there was still inflammation. So he went on Stelara (and was also...
  20. Pangolin

    Crohn's disease happens in clusters, and no one knows why.

    Infection is definitely a possibility for starting Crohn's, but I wouldn't rule out the possibility some non-infectious toxin starting the inflammation cycle. The mouse model in which they induce colitis with DSS may be more similar than you would expect.
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