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  1. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Ok that makes sense - thanks. Ok so what about Qu finding that patient who were previously treated with anti TNF taking longer to respond to their treatment? In other words does long term anti TNF use do permanent damage to the immune system?
  2. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    So Kiny you are basically saying that initially inflix is very effective in causing mucosal healing but in the long term it actually makes things worse - I understand that from reading this thread but how does long term infliximab use effect mucosal healing then?
  3. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    The people in those videos are so lucky - its great for them. They hit a million to one shot and were the first to be treated with QBECO. :)
  4. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Remember patients were only treated for 8 weeks. Longer treatment will yield even better results. Especially for those who have already been on anti TNF's.
  5. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Thanks for that - really interesting read!
  6. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Based on what I've read in this thread, it sounds like in a few decades, they'll look back at giving anti-TNFs chronically as a bit of a crazy idea. Its interesting that those who have been treated with QBECO and have previously been on the anti-TNFs take significantly longer to respond than...
  7. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Go for it - I have no academic training either but everyone is entitled to get involved in the discussion! :)
  8. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Thanks for this - absolutely, there is hope in the future. The main future treatment I was aware of was QBECO. I'm also aware of map vaccine but that's not one I see a great deal of hope in. Will check out the others!
  9. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Good post and I agree. Most of us don't have any choice. The thing that I find most frustrating is that there is hope on the horizon - Qu BIologics being a prime example. In some ways, I am grateful for the biologics as I would be without a colon without them. On the other hand in say 5-10...
  10. Jonny84

    Kind of Feel Like Dying

    PinkThink - having Crohn's does not make you weak. It means you have immense strength. You have done fantastically well to cope with everything that has happened - you should be extremely proud of yourself. Remember there is nothing wrong with asking for help or telling people about your...
  11. Jonny84

    Kind of Feel Like Dying

    Hi PinkThink - welcome to the forum. I am sorry to hear things have become so difficult - I've been where you are just now more than once, My advice would be to identify your fears and try to let them go. I would definitely think about telling your employer about your situation. There is...
  12. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Also on the subject of big pharma research - why has there not been more of an effort to find a replacement for pred? I would have thought this would be one of the highest priorities of IBD research given that in some cases pred can have a worse effect on the body than the disease itself.
  13. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Looks like there are many more options in the pipe line. Is there anything that it not an immune suppressant?
  14. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Treatment gets better incrementally - are things perfect now? Absolutely not but are they better than they were 20 years ago? Definitely. Will they be even better in another 20 years? Of course. As much as its strong medication and there are risks, I'd be without a colon if it wasn't for the...
  15. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    You describe the situation very accurately Crohn2357. That is the way thing are in the world - it's a reflection of who we are collectively as human beings. I believe that an important part of the next phase of our (spiritual) evolution will be rethinking the way we do business. Its happening...
  16. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    But even the current treatments will be replaced. We are talking 5-7 years before QBECO hits the market. In that time there will be a number of new treatments available. Its no more than a question of time - drugs like infliximab may be extremely profitable but they are also very effective in...
  17. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    Good post and many excellent points. I agree they will be falling over themselves to get a hold of this. Can you imagine the impact on share price when the news breaks of owning a possible Crohn's cure? They'll be wetting themselves. In the mean time IBD patients themselves must be the...
  18. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    The treatment (QBECO) is designed to activate an organ specific immune response. In this case by injecting elements of killed e'coli subcutaneously every second day. QBECO recruits activated innate immune cells into the intestinal mucosa, restoring innate immune competency, clearing dysbiosis...
  19. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    I had the most awful experience on LDN - its was a total disaster for me. I know it works for some people but I regret trying it more than I can put into words.
  20. Jonny84

    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    I do absolutely take your point tho. I guess they'll pull out all the stops given that this product has the potential to have a very significant impact on the demand for their current drugs and all drugs that are currently in development.
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