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    New E. coli study

    But then I don't understand if you use ustekinumab to block TH17 proliferation how come AIEC does not spread more? So why immune suppression does not make the disease worse?
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    Lightheadedness and diziness almost unbearable

    Thank you for a lot of help. It was not the easy with the doctors since i posted this but I have found the solution, just as you guys pointed out. The thing is that the docs put me on monthly B12 shots. Ever since I feel good, no neuro symptoms at all. (like 6 months ago) Hope it stays like...
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    Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer Dogs

    Okay, so AIEC infect the macrophage, which in response start producing inflammatory cytokines (like IL-23) to harbour the infection. How come IL-23 antagonist treatment is helping crohn's instead of making it worse. If you are infected with tubercolosis, IL-23 or TNFalpha treatment will make...
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    Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer Dogs

    psoriasis from patient to patient varies a lot, For most its on the elbows, for some its on the legs for some its on the nails. I know 4 psoriasis patient in my close vicinity and every one of them looks totally different. I have both crohn's and psoriasis and it was triggered at a different...
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    Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer Dogs

    If there are people who has crohns in the duodenum, then fecal stream should be called "food".
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    Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer Dogs

    Mine started as a sudden as it can gets. As a child i had fever and took antibiotics (Augmentin). For myself i cant judge if it was the infection or the antibiotics what triggered it but either of the two.
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    New Drug - Mirikizumab

    I wonder how they will compete with other drugs mentioned in the article since they are much more advanced with same or very similar molecules. Maybe competition hopefully reduce the cost of these drugs and will be easier for patients to access it? Also the companies will push harder to reach...
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    Flare after 6 month of succes with Humira, what's the next step?

    I had exactly the same thing, was on Humira every second week since last July, now on every week. For me it helped somewhat. They increased due to calprotectin levels.
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    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    It sounds a bit confusing to me, reading their comment as: "What’s more, the CARD9 protein comes in different variants (alleles) which are passed down from parents to their children. One of these variants (CARD9 rs4077515:A) greatly increases the risk of Crohn’s disease and ulcerative colitis...
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    Remicade anti-TNF therapy has not yielded expected declines in hospitalisation and intestinal resection rates in inflammatory bowel diseases

    QBECO, MAP vaccine etc. have a very small chance to reach market ever. I am optimistic about them but so far the evidence is not close to satisfactory. Bigger Pharma companies are just choosing low risk research directions with biologics. The idea of using biologics other than TNF-alpha is...
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    Lightheadedness and diziness almost unbearable

    Hello, In the previous months i tend to be Lightheaded and dizzy almost the entire day, my pain also is a bit more present at my stomach. Is it possible that the two related? I went to 2 different doctors with it. Both said I am fine. Blood/Vitamins D/folic acid/iron/Blood pressure/glucose...
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    Epstein-Barr (EBV)

    Now, a groundbreaking study by a team from the Cincinnati Children’s Hospital shows that exposure to the Epstein-Barr virus (EBV), best known for causing mononucleosis, appears to boost the risk of developing seven other diseases in individuals who inherited predisposing gene variants. Those...
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