Crohn's Disease Forum » Treatment » Humira/Adalimumab » Vedolizumab and Humira


08-27-2018, 12:32 AM   #1
eagel
 
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Vedolizumab and Humira

Hi
My gastroenterologist is thinking of starting me on Vedolizumab as well as Humira, but my rheumatologist says that one cannot get or be on 2 biological drugs the same time.
So I am wondering who is right.
Is anybody here on Vedolizumab and Humira together, I am from the UK anybody in the UK?
Also is Vedolizumab trial still ongoing?
Thanks
08-27-2018, 11:08 AM   #2
Scipio
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I don't know about the UK, but here in the US treating Crohn's with two different biologics at the same time would be considered very experimental - with unknown safety risks or benefits. Neither drug is FDA approved to be used at the same time as the other.
08-27-2018, 01:54 PM   #3
Maya142
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My daughter has been on two biologics for more than a year. She is doing well. She is on one biologic for her Crohn's (Cimzia) and another for her Ankylosing Spondylitis. We failed absolutely everything else before her doctors were willing to do this and it was insanely hard to get insurance approval. But it can be done.
It is considered "experimental" and she is at a higher risk for infections, but so far, luckily, she has been ok.
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Mom of M (20)
diagnosed with Crohn's Disease at 16
Juvenile Idiopathic Arthritis at 12
Juvenile Ankylosing Spondylitis at 16

Mom of S (23)
dx with JIA at 14
Ankylosing Spondylitis at 18
09-11-2018, 09:00 PM   #4
lgpcarter
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I am on both Humira (2 shots a week) and Entyvio (every 4 weeks) at the moment. Added the Humira in June to try to get fistulas under control, upped to the second shot each week 3 weeks ago after my blood levels came back very low.

My GI has at least one, maybe a couple other patients on two biologics. If Humira doesn't do the trick, I may do Stelara + Entyvio, though, honestly, I am tired and may start to think more seriously about an ileostomy.

I think last time I checked clinical trials.gov there were still some long-term studies on veto happening, but not sure. I have been on it for three years.
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Diagnosed in with Crohn's in large and small bowel in 2000. Fistulas followed soon after.

Seton placement (2) and fistulotomy December 2013. Setons removed July 2014. 3 more setons June 2018.

Laparoscopic Right Hemicolectomy July 2016, 25 cms removed

Current meds: Humira 2 shots weekly, Entyvio every 4 weeks, Vitamin D 2000 IU

Previously: Remicade, Simponi, Pentasa, Sulphasalazine, Entocort, Stelara, Methotrexate, Prednisone, Imuran, Cipro and Flagyl
09-12-2018, 05:22 AM   #5
Guerrero
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What do you mean by vedolizumab trial? It's aproved by almost all the health agencies so i guess yes the classics 1 to 3 stage trials are finished. They always study the efficacy of it compare to other biologics or steroids i think... maybe in combination with other biologics too... you could do some research on ongoing studies or ask your doctor.
As you probably know the mechanisms of entyvio and humira are different so it could make sense to use both.
Good luck and let us know how it goes
09-12-2018, 12:55 PM   #6
Maya142
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I do believe there are some studies that are combining Entyvio with another biologic (I think it was Humira but not sure). I think that is was lpgcarter was saying.
09-13-2018, 02:12 PM   #7
Crohn2357
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https://www.healingwell.com/communit...f=17&m=4062720
09-23-2018, 10:49 AM   #8
lgpcarter
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I do believe there are some studies that are combining Entyvio with another biologic (I think it was Humira but not sure). I think that is was lpgcarter was saying.
Also just longer term studies on the safety of Entyvio.
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