Crohn's Disease Forum » General IBD Discussion » Alternatives for Remicade- Moderate to severe Crohns disease?


11-03-2018, 01:57 AM   #1
chronicallypositive
 
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Alternatives for Remicade- Moderate to severe Crohns disease?

Thoughts? My infusions are only lasting 2.5 weeks now... they used to last the whole 8 weeks, then 6.. then 4... and my dose has tripled since starting it. I think I'm due for a change in the near future.

Remicade is the only biologic I've ever been on since being diagnosed. So I think I have a lot of options?

Thanks-

Ama.
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Crohns for 10 years. Diag. with moderate crohns disease at 11.

Currently on Remicade... and a whole regimen of pills and supplements.

Always trying to keep a happy outlook on any situation.
11-03-2018, 07:35 AM   #2
awoenker12
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Yes, you do have lots of options. Humira, Stelara, Entiyvio, Cimzia are several other biologics that I can think of. Typically, I think Humira is the next step since it is another anti-TNF biologic like Remicade.
11-05-2018, 04:17 PM   #3
Scipio
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All the IBD biologics work by partially suppressing the immune system, thereby reducing the Crohn's inflammation and damage.

In addition to those mentioned above there is also Simponi. Remicade, Humira, Cimzia, and Simponi are all various versions of anti-TNF.

Entyvio is an anti-integrin that tamps down the overactive immune system by decreasing the white blood cells' ability to bind with target cells.

Stelara (my current drug) is anti-IL12/IL23. It binds with the p40 subunit shared by those two molecules and thus reduces the recruitment of white blood cells to the site of inflammation.
12-01-2018, 02:56 PM   #4
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I've had the same issue. Was on remicade for 3 years until it was only lasting about a week, wasn't worth it anymore.

I've been off remicade for a few years but i feel a flare starting. My Dr. wanted me on Humira. He said since its administered more frequently (approx. every 2 weeks), it may give me a boost as the effects from the last injection wears off.

Unfortunately, my insurance decided it won't cover it so I won't get to try it.
12-03-2018, 12:45 PM   #5
Scipio
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Unfortunately, my insurance decided it won't cover it so I won't get to try it.
Will your insurance cover any of the IBD biologics other than Remicade?
12-03-2018, 09:22 PM   #6
Tony_G
 
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Will your insurance cover any of the IBD biologics other than Remicade?
I had a different insurance when I was on remicade, got a new job with different insurance since then.
12-15-2018, 02:21 PM   #7
Poppysocks
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Thoughts? My infusions are only lasting 2.5 weeks now... they used to last the whole 8 weeks, then 6.. then 4... and my dose has tripled since starting it. I think I'm due for a change in the near future.

Remicade is the only biologic I've ever been on since being diagnosed. So I think I have a lot of options?

Thanks-

Ama.
Have you tried modifying your diet a bit? I've been on remicade for the past 18 years, highest doseage. I get it every 4 weeks. If it wasn't for dietary changes, I would have to quit remicade and try something else because remicade alone will not work for me.
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