Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Could azathioprine be insufficient for some Crohn's patients?


04-19-2018, 12:10 PM   #1
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Could azathioprine be insufficient for some Crohn's patients?

Just wondering !
06-19-2018, 05:40 PM   #2
awoenker12
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What do you mean by insufficient? Do you mean to ask that will it not work for some people? In that case yes, azathioprine may not work for everyone. Typically your doctor would ask for a blood test to see if one could metabolize azathioprine at all.
06-19-2018, 07:07 PM   #3
Scipio
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Yes, it is certainly possible for azathioprine to be insufficient for any given patient. It's a pretty good medicine in general, but it doesn't work for everyone and some cannot tolerate the side effects.
06-19-2018, 09:52 PM   #4
Trysha
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It didnít work for me plus I had side effects from it.
If you are having problems it may be best to let your GI know so that treatment can be reviewed.
06-23-2018, 12:14 AM   #5
Lynda Lynda
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I just read an article that said that Crohn's is now termed as an "immune related" disease. It said azathioprine was a "prodrug" of 6mp. It sounded like 6mp and azathioprine are not exactly the same drug? I'm new to this as I was just diagnosed with Crohn's two months ago.

I have been taking 6mp for 6 weeks. I have routine blood draws. No major side effects.

Take Care
06-23-2018, 02:36 AM   #6
emmaaaargh
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I just read an article that said that Crohn's is now termed as an "immune related" disease. It said azathioprine was a "prodrug" of 6mp. It sounded like 6mp and azathioprine are not exactly the same drug? I'm new to this as I was just diagnosed with Crohn's two months ago.

I have been taking 6mp for 6 weeks. I have routine blood draws. No major side effects.

Take Care
Lynda, azathioprine being the prodrug of 6MP means that azathioprine is converted into 6MP in the body. You get the same end result when you take either one, but some people find that taking 6MP directly instead of azathioprine gives them fewer side effects (because the body has to do less work in converting the drug into the active form)
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Hi, I'm Emma!
20 years old.
Diagnosed: Crohn's disease, August 2007
Currently on: Inflectra 5 mg/kg, azathioprine 37.5mg
06-23-2018, 07:26 PM   #7
Lynda Lynda
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.....

Last edited by Lynda Lynda; 06-24-2018 at 02:29 AM. Reason: Too Long
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Crohn's Disease Forum » Treatment » Imuran/Azathioprine/6-MP » Could azathioprine be insufficient for some Crohn's patients?
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