Crohn's Disease Forum » Treatment » Methotrexate » Blurred vision on Methotrexate


09-25-2018, 10:33 PM   #1
Terry
 
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Blurred vision on Methotrexate

Hi, I have been on Methotrexate for about 3 years now for Crohns disease. Something I have noticed is I take my Methotrexate on Wednesday late afternoon, and come Sunday I develop blurred vision which last 2 to 3 days. I feel it is getting worse and seems to be lasting longer. Anyone else have this problem and is this a common side effect of the drug. I would appreciate any feedback. Thanks.
__________________
iagnosed 1988 Crohns Disease.
Finished with Prednisone September 2013
Not on any Meds except Somac 40mgx2 daily
Right Hemicolectomy April 2014
Vitamin B12 injections 3 monthly.
09-26-2018, 07:34 AM   #2
eleanor_rigby
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Somerthing I found online:

Methotrexate-related ocular toxicities consist of peri-orbital edema, ocular pain, blurred vision, photophobia, conjunctivitis, blepharitis, decreased reflex tear secretion and non-arteritic ischemic optic neuropathy.
The optic neuropathy has been linked to folate deficiency, either nutritional or genetic. Folate supplementation when co-administered with methotrexate, minimizes its adverse effects and may therefore prevent the development of optic neuropathy. In addition, when this condition is recognized, the nerve damage can be reversed if methotrexate is stopped and appropriate folate supplementation is administered promptly.

I would suggest you start taking folate supplements if you aren't already? I know a lot of people take them with this medication.

Make sure to let your doctor know, you may need to stop this med.
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History:
2nd Generation affected

Symptoms since 08/2006 (age 17)

Emergency open bowel resection after perforation in 12/2011 (age 22) (wrongly diagnosed as burst appendix ). Three years remission following this unmonitored

Diagnosis:
Perforating small bowel Crohn's Disease 01/2016 (terminal ileum, duodenum)
Coeliac disease (age 26)

Meds:
50mg azathioprine (down from 75mg after my WBC dropped)
Gluten-free diet
09-28-2018, 07:31 PM   #3
Terry
 
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Thanks eleanor_ rigby for your reply, I am taking folate 5mg for the following 2 days after the methotrexate dose. I was interested to see if anyone else has this problem. I am seeing my GI in about 3 weeks so I will have a chat to him about the blurred vision, its taken me a long time to see a pattern of when this vision starts to go funny. Thanks again for your input, hope you are well. Terry.
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