Crohn's Disease Forum » Books, Multimedia, Research & News » Immunomodulators may not be necessary alongside stelara


10-15-2018, 03:35 AM   #1
eleanor_rigby
Senior Member
 
Join Date: Aug 2012
Location: Cheshire, England, United Kingdom

My Support Groups:
Immunomodulators may not be necessary alongside stelara

https://www.healio.com/gastroenterol...rapy-in-crohns
10-15-2018, 09:38 AM   #2
Crohn2357
Senior Member
 
Crohn2357's Avatar
 
Join Date: Aug 2013

My Support Groups:
I think more and longer term research with more patients is needed on this to be sure.
10-19-2018, 11:42 AM   #3
Tuff
Senior Member
 
Tuff's Avatar
 
Join Date: Feb 2013
Location: Ontario

My Support Groups:
In my experience, I used Stelara alone for a year, and then flared badly. After Methotrexate was added, I'm in remission again. But who knows for how long. I agree with the long term research. I think they tend to publish too soon.
National Institute of Health:
Frequent publication is one of the few powerful methods at scholar's disposal to demonstrate academic talent to peers. Successful publication of research brings attention to scholars and their institutions. This in turn may bring in more funding for the institute and also ensure an individual's progress through their field.
10-19-2018, 05:12 PM   #4
Scipio
Senior Member
 
Scipio's Avatar
 
Join Date: Oct 2015
Location: San Diego

My Support Groups:
∑ Stelara
I'm coming up on my one year mark on Stelara alone. So far so good. If I had to I might consider adding methotrexate, but I really do not want to go on azathioprine.
10-19-2018, 06:24 PM   #5
my little penguin
Forum Monitor
 
Join Date: Apr 2012

My Support Groups:
Ds has been on Stelara over a year with methotrexate
No issues
(Mtx is added for arthritis prior to Stelara)
__________________
DS - -Crohn's -Stelara -mtx
10-21-2018, 03:01 AM   #6
Crohn2357
Senior Member
 
Crohn2357's Avatar
 
Join Date: Aug 2013

My Support Groups:
I really do not want to go on azathioprine.
Bad experience?
10-22-2018, 10:29 AM   #7
Scipio
Senior Member
 
Scipio's Avatar
 
Join Date: Oct 2015
Location: San Diego

My Support Groups:
∑ Stelara
No Not a bad experience. It's concern about risk. The risk of lymphoma induced by azathioprine goes up sharply after age 50 and way up even more after age 60. If I were say 30 years old I wouldn't be nearly as concerned.
10-22-2018, 10:51 AM   #8
eleanor_rigby
Senior Member
 
Join Date: Aug 2012
Location: Cheshire, England, United Kingdom

My Support Groups:
No Not a bad experience. It's concern about risk. The risk of lymphoma induced by azathioprine goes up sharply after age 50 and way up even more after age 60. If I were say 30 years old I wouldn't be nearly as concerned.
Gah thatís what I take but Iím 30. Hereís to hoping thereís something else that doesnít compromise the immune system available in 20 years time!
10-22-2018, 11:14 AM   #9
Crohn2357
Senior Member
 
Crohn2357's Avatar
 
Join Date: Aug 2013

My Support Groups:
What makes me concerned about MTX is its neurotoxicity.
10-22-2018, 03:10 PM   #10
Maya142
Forum Monitor
 
Maya142's Avatar
MTX is used at tiny doses for Crohn's - usually the highest dose is 25 mg. For cancer, it's used in much, much higher doses - like 1000 mg and up.

Neurotoxicity is not usually a concern at the doses used for Crohn's. The common side effects are nausea, fatigue, mouth ulcers. They can be treated with Zofran (for the nausea) and folic acid for everything else.
__________________
Mom of M (20)
diagnosed with Crohn's Disease at 16
Juvenile Idiopathic Arthritis at 12
Juvenile Ankylosing Spondylitis at 16

Mom of S (23)
dx with JIA at 14
Ankylosing Spondylitis at 18
Reply

Crohn's Disease Forum » Books, Multimedia, Research & News » Immunomodulators may not be necessary alongside stelara
Thread Tools


All times are GMT -5. The time now is 12:11 PM.
Copyright 2006-2017 Crohnsforum.com