04-04-2018, 09:24 PM   #1
DCCrohns
 
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Stem Cell Therapy

I know it's a long-shot, but has anyone participated in a trial to treat their fistula(s) using mesenchymal stem cells (i.e., those harvested from you)?

I've tried it all and am about to start a clinical trial at Mayo using a MSC-coated fistula plug in hopes that it helps me with my RVF (developed after successful surgical treatment of an anal fistula). They've used this therapy on anal fistulas and had promising results, so I am hopeful that this less-invasive approach will make a difference (and allow me to be reconnected).

Here's to being a guinea pig!
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Diagnosed with Crohn's: 2002
Past Meds: Pentasa, Remicade, Cimzia, Asacol, Cipro, Flagyl, Lialda, Humira
Current Meds: Stelara (4 weeks) , Azathioprine (150mg/day)

Surgeries: Fistulotomies & Seton Placements (2011, 2013); Advancement Flap (2013); Temp Loop Ileostomy (2016); Fistula Repair w/ Gracilis Muscle (2016); Fistula Repair (2016); Seton Placement & Stem Cell Harvesting & Stem Cell Placement (2018)
04-05-2018, 06:54 PM   #2
cmack
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Best of luck, I hope you have complete success.
04-07-2018, 06:57 PM   #3
Lady Organic
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yes, that is very interesting. I remember posting some results here:

http://www.crohnsforum.com/showthread.php?t=82860

Are you participating with one of those hospitals involved in this study?

All the best luck to you!
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''UC-like Crohn's'' (2001)
wrists + ankles arthropathies (2013)
on: Humira
Diet: ''IBD-AID'' : http://www.nutritionj.com/content/13/1/5+ organic food only, Vitamin D + B12 shots
Past meds: prednisone 50mg, 5-ASA (pill, rectal), cortifoam, cortenema, Imuran, Purinethol, methotrexate.
04-09-2018, 09:05 AM   #4
DCCrohns
 
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Thanks for sharing! This is the trial I am participating in (at Mayo):

https://clinicaltrials.gov/ct2/show/NCT03220243

They have completed similar trials with other fistula patients with promising results (around 80% healing a year out, I believe). Main difference here vs. some others is that instead of just injecting stem cells they use a plug to deliver them and, theoretically, enhance the effectiveness.
04-10-2018, 03:10 PM   #5
Crohn2357
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https://newsnetwork.mayoclinic.org/d...complications/

If anyone is interested.
04-29-2018, 01:40 PM   #6
mish2575
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Cant wsit to hear your results
04-29-2018, 03:35 PM   #7
DCCrohns
 
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Just had my first trip to Mayo and visit #1 (EUA, seton placement and stem cell harvesting) is in the books. All went well and I should be headed back in about two months for the plug/stem cells. Feeling hopeful...
04-29-2018, 07:09 PM   #8
Lady Organic
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Nice! really wishing you well!
04-29-2018, 09:36 PM   #9
cmack
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Nice! really wishing you well!
Same here!
06-09-2018, 10:12 AM   #10
Mm12
 
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Please tell me where, when and who yo contact for surgery at MAYO. Please
06-09-2018, 10:22 AM   #11
Mm12
 
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Please tell me how I can become a guinea
Pig??!!
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