Crohn's Disease Forum » Parents of Kids with IBD » Enlarged Lymphnode And Rash Humira

05-15-2019, 10:41 AM   #1
Join Date: Jan 2018
Location: Illinois
Enlarged Lymphnode And Rash Humira

Hi! My daughter started Humira 2 months ago. It seems like since
then she has developed what looks like a heat rash on her
Trunk. It’s also itchy. She’s been tested for mono and strep, both negative. She also has a few enlarged lymph nodes just above her
Collarbone on her right side only. She’s had an ultrasound and they just show enlarged. Not suspicious or infected. Anyone have children on Humira or Remicade with lymphnode reactions or who developed a rash? She has appt with ID but she doesn’t have any other symptoms such as fever.
05-15-2019, 10:55 AM   #2
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Maya142's Avatar
Have you seen a dermatologist to figure out what the rash is? Sometimes a biopsy is necessary to figure out the rash.

I'm going to tag other parents since I don't have a lot of experience with rashes - my daughters have both been on Humira but didn't have side effects.

my little penguin
Mom of M (20)
diagnosed with Crohn's Disease at 16
Juvenile Idiopathic Arthritis at 12
Juvenile Ankylosing Spondylitis at 16

Mom of S (23)
dx with JIA at 14
Ankylosing Spondylitis at 18
05-15-2019, 11:53 AM   #3
my little penguin
Forum Monitor
Join Date: Apr 2012

My Support Groups:
Heat rash
Please see a dermatologist familiar with biologics
Ds has this woth remicade
We were told it was drug eruption rash (basically from the remicade )
It came and went until Ds had an allergic reaction to remicade

Ds was in humira for close to 5 years when a large cervical lymph node (jaw line appeared )
No fevers
ID monitored it for a month
Tested for lots of things including cat scratch disease
Hmm wasn’t that
Sent us to ent since it continued to grow
Inpatient two days of iv abx (no sign of infection in any of the ultrasound s)
They decided to do a needle biopsy (this test is useless and didn’t answer anything )
Next day had a excisional biopsy (removed the entire lymph node
-it was 3.5 cm wide by that point )- left the smaller ones

Cultured it and let things grow for three months
Nothing infectious showed up
He did have multiple granulomas in it
Which we were told were due “autoimmune disease “ by some of his docs
Other doctors said the granulomas were from crohns

After all that they tried humira again
It failed to work and was switched to stelara

Hope it helps
DS - -Crohn's -Stelara -mtx
05-15-2019, 02:23 PM   #4
Senior Member
Join Date: Dec 2014
Location: Portland, Oregon

My Support Groups:
My daughter has been on Remicade for 4 years, and while she hasn't had a rash like you describe, she's definitely had some derm issues. She had Remicade-induced psoriasis on her scalp for several months; once she restarted methotrexate, that went away completely. She also gets a pimply rash on her legs in the summer, usually when she starts shaving her legs again. Her doctors say it's folliculitis, and it responds pretty well to topical antibiotics. I know that you don't have to be on biologics to suffer from folliculitis, but I think she's extra prone to it because of her immune suppression.

Anyway, I think it's good that you have an appt with ID, and seeing a dermatologist would probably be good too. Good luck with figuring out what's going on, and I hope it turns out to be easily treatable.
Daughter E (16) dx with Crohn's 12/18/14 at age 12

Current treatment:

Remicade started 12/24/14 (9 mg/kg every 6 weeks)
Methotrexate restarted 12/2/16 (15 mg weekly)
vitamin D, folic acid, multivitamin, Prozac

Past Treatment
90% EN via NG tube 2/9/15 - 4/2/15
50% EN via NG tube 4/3/15 - 4/18/15
Supplemental EN via NG tube 5/7/15-6/19/15
Budesonide 3/3/15-6/30/15, 3/24/18-5/18/18
Methotrexate 3/13/15 - 5/14/16 (15 mg weekly)
Clobetasol for Remicade-induced psoriasis
05-15-2019, 03:30 PM   #5
Senior Member
Join Date: Mar 2012
Location: California

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Adding to the choir on the derm suggestion. The anti tnf's cause lots of skin issues most of them benign.

Both of my daughters have Remicade induced psoriasis. In their scalps it is thick plaques but my one daughter has it on her stomach and it is a. red pimple like rash and itches. The derm can probably take one look at it and let you know what it is.

Both of my girls have also had swollen lymph nodes numerous times. It has always been nothing but good you had it checked out and are watching it.
Daughter O dx 2/1/12 at age 12
Crohns & Remicade induced Psoriasis
Vit d 2000IU
Multi vitamin plus iron

Previously used - Prednisone, Prevacid, Enteral Nutrition, Methotrexate oral and injections, Folic Acid, Probiotics, Cortofoam

Daughter T dx 1/2/15 at age 11
Vitaligo, Precoscious puberty & Crohn's
Vit D 2000IU

Previously used, Exclusive Enteral Nutrition, Methotrexate (injections and oral), Folic Acid, Entocort,IBD-AID Diet
05-16-2019, 07:32 AM   #6
Join Date: Jan 2018
Location: Illinois
Thank you for all of the feedback! It always helps to hear from other parents. Seeing the GI today and ID next week. Thanks everyone!

Crohn's Disease Forum » Parents of Kids with IBD » Enlarged Lymphnode And Rash Humira
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