Hi Lisa,
Tell me, how long have you been on
methotrexate for? Just make sure to discuss that itching issue with you GI tomorrow. I am assuming that it will ring him the same bell it does for me, which is a potential link of hepatoxicity (yep, mtx can sometime be harsh on the liver). In theory, you would also have anomalies of your LFT (ALT (would be raised),
AST, albumine level, these kind of test) but sometimes, it does not show up and itchy hand and feet can be signaling that something is wrong on that aspect.
I know I've read quite a bit before I took it two years ago and I came across some paper that were suggesting that patient that would use it for psoriasis and RA where requested to have liver biopsies at some point to make sure that the liver was in proper order. This was when the medication was used long-term (somewhere above 1,5g of mtx (roughly after 2 years for a 15mg/wk regimen, sooner or later according to the specific dosage)). I don't think they do that regularly unless you have condition that suggests that you would be prone to liver disease or so.
I hope I am not scaring you here. It is just to give you certain information that allows you to speak to your GI accordingly. I'm sharing what I would have been asking if I had been in your situation. If he says there is no chance that this is what is happening to you then you will just be glad and happy it isn't and the other way around is also through. If ever your liver was getting tired of the medication then it is better to know it and the condition is generally reversible too.