Crohn's Disease Forum » Books, Multimedia, Research & News » Effectiveness and safety of vedolizumab in adult patients with inflammatory bowel disease


08-16-2018, 02:50 PM   #1
Lady Organic
Forum Monitor
 
Lady Organic's Avatar
 
Join Date: Apr 2013
Location: Montréal, Quebec

My Support Groups:
Effectiveness and safety of vedolizumab in adult patients with inflammatory bowel disease

''A real-world, long-term experience on effectiveness and safety of vedolizumab in adult patients with inflammatory bowel disease: The Cross Pennine study.''

https://www.ncbi.nlm.nih.gov/pubmed/30077465

Abstract

BACKGROUND:

Real-life data on vedolizumab effectiveness in inflammatory bowel disease (IBD) are still emerging. Data on the comparative safety of the gut selective profile are of particular interest.

AIMS:

To assess clinical outcome and safety in IBD patients treated with vedolizumab.

METHODS:

We retrospectively collected data of patients treated with vedolizumab at eight UK hospitals (August 2014-January 2018). Clinical response and remission at 14 and 52 weeks evaluated through Physician Global Assessment (PGA) and adverse events were recorded. Possible predictors of clinical response were examined.

RESULTS:

Two hundred and three IBD patients (mean treatment 16 ± 8 months) were included. Of these, 135 patients (mean age 40.6 ± 16.0 years; F:M 1.9:1) had CD and 68 (mean age 44.5 ± 18.1 years; F:M 1:1.2) had UC. According to PGA, 106/135 (78.5%) CD and 62/68 (91.2%) UC patients (p = 0.02) had a clinical response/remission at 14 weeks, whereas 76/119 (63.9%) CD and 52/63 (82.5%) UC patients (p < 0.01) showed a sustained response or remission at 52 weeks, with a high adherence rate (97%). No predictors of clinical response were found. The cumulative incidence of infectious diseases was 11.9 per 100 person-years.

CONCLUSION:

Vedolizumab is an effective therapy for inducing and maintaining remission of IBD, with better results for UC, and with a good safety profile.


******Is this me or these results seem to be better than those of Humira and Remicade for both CD and UC???****
__________________
''UC-like Crohn's'' (2001)
wrists + ankles arthropathies (2013)
on: Humira
Diet: ''IBD-AID'' : http://www.nutritionj.com/content/13/1/5+ organic food only, Vitamin D + B12 shots
Past meds: prednisone 50mg, 5-ASA (pill, rectal), cortifoam, cortenema, Imuran, Purinethol, methotrexate.
Reply

Crohn's Disease Forum » Books, Multimedia, Research & News » Effectiveness and safety of vedolizumab in adult patients with inflammatory bowel disease
Thread Tools


All times are GMT -5. The time now is 09:05 PM.
Copyright 2006-2017 Crohnsforum.com