I have been on Ldn for 10 weeks and i feel pretty good. 3 trips a day and no beeding except for the odd day every ten days when i may notice a speck but not real sure if it is blood or something else. I still think i have a small fissure but it is so much better. My energy is good and i am happy. Anyway tomorrow i go for a flex sig so that will be a good test to see if things are really improving. I have a question. My sig is scheduled for 7:30 a.m. so can I take Ldn tonight at 11:00 p.m. like i normally do. I know they give me twilight sedation and i never remember anything. Tomorrow i will post my results. Thanks in advance for any insight on this issue.