https://academic.oup.com/ecco-jcc/article/5/3/222/468526
Results: Thirty two patients (mean age 13.1 ± 3.9, mean duration of disease 0.65 years) were included, of whom 21 (66%) entered clinical remission (PCDAI < 10) after 8 weeks of treatment. The mean age at treatment and duration of disease did not differ between patients entering remission and those unresponsive to therapy. CRP, normalized in 54% of patients with elevated CRP at baseline. Factors associated with lack of response were a more severe disease (reflected by higher PCDAI and CRP values at baseline), presence of arthritis and extensive disease (ileocolonic, or prominent upper intestinal disease).
Conclusions: An 8 week course of azithromycin and metronidazole therapy may be effective in inducing clinical remission in mild-moderate luminal CD in children and young adults.
Results: Thirty two patients (mean age 13.1 ± 3.9, mean duration of disease 0.65 years) were included, of whom 21 (66%) entered clinical remission (PCDAI < 10) after 8 weeks of treatment. The mean age at treatment and duration of disease did not differ between patients entering remission and those unresponsive to therapy. CRP, normalized in 54% of patients with elevated CRP at baseline. Factors associated with lack of response were a more severe disease (reflected by higher PCDAI and CRP values at baseline), presence of arthritis and extensive disease (ileocolonic, or prominent upper intestinal disease).
Conclusions: An 8 week course of azithromycin and metronidazole therapy may be effective in inducing clinical remission in mild-moderate luminal CD in children and young adults.