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A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice
- Thread starter sir.clausin
- Start date
man you are finding some good stuff here.this is another observation the commensal(good) clostridia seem to play an important role in the immune system. and this directly supports the theory that their extinction in the gut of IBD patients may be the main cause of the disease or the chronic inflammation.
nice work!
nice work!
np man, sharing the same idea
just an article about what il-10 is and what it does.
Annu Rev Immunol. 2011;29:71-109. doi: 10.1146/annurev-immunol-031210-101312.
Regulation and functions of the IL-10 family of cytokines in inflammation and disease.
Ouyang W, Rutz S, Crellin NK, Valdez PA, Hymowitz SG.
Source
Department of Immunology, Genentech, Inc., South San Francisco, California 94080, USA. ouyang@gene.com
Abstract
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family cytokines emerged before the adaptive immune response. These cytokines elicit diverse host defense mechanisms, especially from epithelial cells(LIKE THE INTESTINE!), during various infections. IL-10 family cytokines are essential for maintaining the integrity and homeostasis of tissue epithelial layers. Members of this family can promote innate immune responses from tissue epithelia to limit the damage caused by viral and bacterial infections. These cytokines can also facilitate the tissue-healing process in injuries caused by infection or inflammation. Finally, IL-10 itself can repress proinflammatory responses and limit unnecessary tissue disruptions caused by inflammation. Thus, IL-10 family cytokines have indispensable functions in many infectious and inflammatory diseases.
Annu Rev Immunol. 2011;29:71-109. doi: 10.1146/annurev-immunol-031210-101312.
Regulation and functions of the IL-10 family of cytokines in inflammation and disease.
Ouyang W, Rutz S, Crellin NK, Valdez PA, Hymowitz SG.
Source
Department of Immunology, Genentech, Inc., South San Francisco, California 94080, USA. ouyang@gene.com
Abstract
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family cytokines emerged before the adaptive immune response. These cytokines elicit diverse host defense mechanisms, especially from epithelial cells(LIKE THE INTESTINE!), during various infections. IL-10 family cytokines are essential for maintaining the integrity and homeostasis of tissue epithelial layers. Members of this family can promote innate immune responses from tissue epithelia to limit the damage caused by viral and bacterial infections. These cytokines can also facilitate the tissue-healing process in injuries caused by infection or inflammation. Finally, IL-10 itself can repress proinflammatory responses and limit unnecessary tissue disruptions caused by inflammation. Thus, IL-10 family cytokines have indispensable functions in many infectious and inflammatory diseases.
just found this article, it is related to butyric acid producing bacteria in the gut and their benefits in IBD.
Published in the journal Nature today, the Japanese study shows that butyrate, a by-product of the digestion of dietary fiber by gut microbes, acts as an epigenetic switch that boosts the immune system by inducing the production of regulatory T cells in the gut. The research sheds light on the role of gut bacteria on the maturation of the immune system and provides evidence supporting the use of butyrate as therapy for inflammatory bowel diseases like Crohn's disease.http://www.sciencedaily.com/releases/2013/11/131113132202.htm
Cultural and molecular studies indicate that the most numerous butyrate-producing bacteria found in human faeces are highly oxygen-sensitive anaerobes belonging to the Clostridial clusters IV and XIVa
http://www.ncbi.nlm.nih.gov/pubmed/12480096 dopt=Abstract&holding=f1000,f1000m,isrctn
FYI, these clostridia are the group of bacteria that found to be "missing" or extinct in IBD patients. they make up to 40% of all the species found in the human gut, so they are likely to be important.
Published in the journal Nature today, the Japanese study shows that butyrate, a by-product of the digestion of dietary fiber by gut microbes, acts as an epigenetic switch that boosts the immune system by inducing the production of regulatory T cells in the gut. The research sheds light on the role of gut bacteria on the maturation of the immune system and provides evidence supporting the use of butyrate as therapy for inflammatory bowel diseases like Crohn's disease.http://www.sciencedaily.com/releases/2013/11/131113132202.htm
Cultural and molecular studies indicate that the most numerous butyrate-producing bacteria found in human faeces are highly oxygen-sensitive anaerobes belonging to the Clostridial clusters IV and XIVa
http://www.ncbi.nlm.nih.gov/pubmed/12480096 dopt=Abstract&holding=f1000,f1000m,isrctn
FYI, these clostridia are the group of bacteria that found to be "missing" or extinct in IBD patients. they make up to 40% of all the species found in the human gut, so they are likely to be important.