Hi Ezio! I have been on the Vedolizumab Phase III Study for 10 weeks now. This is the 1st drug I have used in 41 years that has helped me! It is very user friendly. I have had no clinical side effects at all. The only problem I had is that 12 days after the infusion I got nauseated for 2 days. The doctor really doesn't believe it should be related to the drug, but what I am eating. I went from having 10 bowel movements a day down to only 3. That in itself is worth it!! I had breakthrough pain only once, although when I press on the infected area it still hurts. No other side effects!! I love it! If you have any questions please ask me, it seems I am the only person on this medication.