• Welcome to Crohn's Forum, a support group for people with all forms of IBD. While this community is not a substitute for doctor's advice and we cannot treat or diagnose, we find being able to communicate with others who have IBD is invaluable as we navigate our struggles and celebrate our successes. We invite you to join us.

Advice on what meds I can try next?

Currently on Stelara & it has been working somewhat. I take imuran and probiotics along with it.

My GI has told me that I have failed all other meds, and when I flair next it will either be experimental meds as surgery is not a good option for me. I developed antibodies to humira, so GI says this means that I can not take biologics anymore.

I have been on, Methotrexate, pentasa, remicade, sulfa, antibiotics, 6mp, humira, and asacol. Might be missing a few on this list.

Anyone got any suggestions that are not biologics? I’m feeling ok right now, but we all know that tomorrow that may change.

Thanks, whoops
Thanks, me too. However, I have to be realistic and at least be researching other option. The Stelara could give me 10 more years, or 10 more days. I hate this disease!

my little penguin

Staff member
If you only have antibodies to humira
Then Remicade is still available
As well as cimizia /Simponi
Stelara can be bumped to 90 mg every 4 weeks
But it does take 6 months to be effective
There is also ivig for refractory Crohns

Any biologic can have mtx added to it

You can also partial een (exclusive enteral nutrition-formula)
Which helps biologics last longer
Ds drinks 50% of his calories from neocate jr .

Good luck
I developed antibodies to humira and some other component to it. It took a seven day hospital stay, and 4 GI docs to figure it out. And some pretty expensive lab work too.
Upping the Stelara would be an option I didn’t think about. I didn’t think about EEN thanks for the input. Definitely options to look into.
Thanks, woops


Staff member
Even if you developed antibodies to Humira, you can still try other anti-TNFs like Cimzia or Simponi. What do you mean by "some other component to it"?

There is also Entyvio (vedolizumab). That is not an anti-TNF.

Then there are drugs in trials - there are multiple IL-23 inhibitors in trials. One of them has been approved for psoriasis already and is now being tested in Crohn's.

Then there is Tofacitnib - Xeljanz. It is a JAK inhibitor and a biologic but is taken in the pill form. It did not do well for Crohn's in trials but should be approved for UC next year. Might also be worth trying. It has been approved for RA for years and was just recently approved for psoriatic arthritis.

You could also try a diet, like the IBD AID: https://www.umassmed.edu/nutrition/ibd/ibdaid/