• Welcome to Crohn's Forum, a support group for people with all forms of IBD. While this community is not a substitute for doctor's advice and we cannot treat or diagnose, we find being able to communicate with others who have IBD is invaluable as we navigate our struggles and celebrate our successes. We invite you to join us.


Hello, I am a 48 year old male located in Canada. I have been recently diagnosed with mild Crohns in my terminal ileum. Recently, my GI specialist had prescribed amitriptyline at 10 mg a day. I have been taking this medicine for a week and was wondering when it usually takes effect?


Staff member
Hi there, sorry its taken a little while to respond, what symptom is your doctor hoping the amitriptyline will help with? I personally take it to help with another condition called cluster headaches and in my case the main aim is helping with sleep. I know for some people it can also help with pain. The dose you're on is relatively low so you may need an increase, generally it takes Up to four weeks for the drug to take full effect. How is your doctor treating your Crohn's itself?
I have seen research that shows the possibility of amitriptyline having an anti-inflammatory effect on Crohn's disease but I've not seen it used as front line treatment.