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Anaphylaxis after fourth remicade

I had my fourth remicade infusion and suffered anaphylactic shock and was hospitalised .i have suffered with horrific nausea and diorrea on all oral meds and now my doctor doesn't know where we go next .... Worried I may react to humira . I have a recto vaginal fistula and suffer with my crohns symptoms daily . Any advice ??:sign0085:
Since Remicade is made from both human and animal sources and Humira is made only from human sources, they are not chemically the same thing. Hopefully after you try Humira, you will have success and whatever you are allergic to was only in the Remicade.
Are you also on 6MP? I was told that allergic reactions occur less frequently when trying a biologic if you are also on 6MP.

Feel better soon and hope you find something fast that works for you!
Thanks snicker doodle , my consultant doesn't want to risk me trying humira and feels surgery may be the next step , as he says it was very rare to react after fourth infusion , the fistula is the worst , embarrassing , and painful , due to see doc next week , so will see what he comes up with , not sure what 6mp is, currently on nothing :poo:
You can try a skin prick test with Humira
DS has had anaphylaxis to food as well as numerous drug reactions including two to remicade.
When someone is allergic to something the allergist takes a small amount and pricks the skin( barely ) to see if the person's skin reacts and comes the hive that forns to the control hive that forms from saline water prick
Above a certain size it's considered a positive reaction.
We had this done for DS when he had satellite gives around his Humira injection site early on.
No skin reaction and he has been on the drug for 2.5 years now.

Remicade has a 1% chance of having a reaction due to the murine protein
Humira risk of reaction is extremely small
Maybe the skin prick test might be sonething the GI would agree to before surgery
My child reacted severely from Remicade and too was hospitalized from anaphylaxis. Her GI was hesitant to try any other biologic, but after doing some research she discovered the reaction to Humira is extremely low, mostly for the reasons given above.

My kid went onto Humira, but had to do her loading dosages in hospital and be monitored for a reaction. After about 6 hrs we went home. She never had an alert reaction to any biologic since Remicade.

That being said, we waited about 3 months between Remicade & Humira.

Hope this helps.
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Lady Organic

Staff member
methotrexate is an old medication more common in rhuematology but used for IBD too. have you tried it?? it can be given by self weekly injection, which is the prefered route of administration for this medication. can be in combo with Humira too.
Thankyou for advice people , saw gp today as terrible night of diorrea and fever , chills , cold but temperature etc . Consultant wants me back on anti biotics and prednisolone , despite it giving me d and v previously , will give it a try , feeling miserable x
Didn't mention , bad reactions to azathiripine and 6 mp ,:sign0085:
Had the same issue with the remicade after the 3rd or 4th infusion. Was put on Humira with no reaction. It didn't work for me but may for you if you can get on it. But then I would listen to the DR before anyone on the net :) If surgery is suggested then I would suppose its been well thought out by your DR.

Lady Organic

Staff member
pjm357;872931 But then I would listen to the DR before anyone on the net :) If surgery is suggested then I would suppose its been well thought out by your DR.[/QUOTE said:
I disagree with that. a forum such as this one is plenty of valuable information we can bring to our doctors for discussion and participation in our case. we can mix our personal research with the doctor's knowledge. Doctors dont know everything, such as ongoing clinical trials we can enroll in and cant never predict the outcome of the disease on a patient X with 100% certainty. I had a terrible experience in that regard. I had been sent to hand surgery by a rhuematologist because this dr was out of options for me. I had to see a third hand surgeon who finally diagnosed my real condition, arthritis. The 2 previous (young) hand surgeons were ready to operate me for another condition i didnt even have!!!. I was so miserable depressed and anxieous for a whole year, mostly because of the incompetence of 3 specialists doctors.... The rhuematologist was a closed minded person, not open to discussion and ceratinly didnt have time to explore all avenues with me. I was simply a fast number in the big case load. Im not saying this is the case in this thread, but always keep in mind that it is always good to participate in decisions, because some people do get unlucky with wrong advice.
conclusion, best to ask for a second, third opinion and make some personal research on possibilities before undergoing any big move. good luck.
Pjm Though I agree a doctor is who you should get your treatment. Some GI's aren't informed or caught up on the latest. My kid's previous GI thought once Remicade fails you can't take another biologic. It was a study here I brought to her that she took and discussed with other GI's to confirm Humira was an option.

GI's can't be everywhere nor can anyone else. Your doc sometimes just needs more info to make a more educated decision. It is your job as patient to advocate for yourself.