Andrographis paniculata, herbal supplement compares to Mesalazine in study

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http://examine.com/supplements/Andrographis+paniculata/

In treating Ulcerative Colitis:

"Appears to be quite effective based on preliminary evidence, with one study being comparable to sustained release mesalazine in potency."


Two studies referenced:
http://examine.com/rubric/effects/view/324/Symptoms+of+Ulcerative+Colitis/all/

Goes Well With:

Siberian Ginseng (Eleutherocossus Senticoccus)
P-Glycoprotein inhibitors (increase absorption when Andrographis is taken at high doses)

On side effects and toxicity:

In interventions with Andrographis Paniculata, side-effects do not appear to be significantly different than placebo[8][2][25][1] even in one instance where side-effects reached 20% of the study group (same as placebo, suggesting another factor was at play);[42] most reported side-effects (regardless of being different or similar as placebo) generally being mild and infrequent.[7]

One study in HIV positive persons has noted that, with isolated Andrographolide, some symptoms similar to an allergic reaction were reported (from two subjects, no placebo group in this study)[40] while according to manufacturers (data retrived here[7]) there have been 5 reported cases of allergic reactions associated with Andrographis Paniculata supplementation.

In general, human intervention data appears to show that commonly used doses of Andrographis Paniculata are safe; very few instances of allergic reactions or something sharing the symptoms has been reported
In rats, the LD50 appears to be greater than 17g/kg.[78]