Anti-TNFs such as Remicade or Humira were shown to be less effective at inducing remission when given as a first biologic to patients older than 60 years vs. those younger than 60 years. Older patients showed a 38% clinical remission rate vs 61% for younger patients after 52 weeks of anti-TNF treatment.
Elderly onset age is associated with low efficacy of first anti-tumor necrosis factor treatment in patients with inflammatory bowel disease - Scientific Reports
The outcomes of patients with elderly onset (EO) inflammatory bowel disease (IBD) treated with anti-tumor necrosis factor (TNF) remains uncertain. The present study evaluated the efficacy and safety of anti-TNF treatment for bio-naïve EO-IBD. Elderly patients were defined as those 60 years and...