I have twins who were both diagnosed with Crohn's about a year ago as young adults. In both cases, it is limited to their colons. They have no abcesses. My one son got quite sick a year ago - he was rapidly losing weight and just lay around the house (very unusual for him). While we were waiting to see a gastroenterologist and feeling quite desperate, his PCP prescribed a round of Metronidazole. The PCP had already performed a number of tests and was pretty clear the only problem was IBD. Before my son was even finished with the course of antibiotics, he was feeling great, and he was back to eating and all of his usual activities. Bottom line - the only dramatic improvement in either of my sons came with this antibiotic; biologics don't seem to be having enough affect (at least the ones we've tried so far). When my sons were first diagnosed, we spoke with literally five top IBD specialists around the country (I know some of you will think that was going overboard, but it was helpful to us, and during the pandemic, it was possible to have lots of virtual appointments). When we mentioned to any of these specialists how well the Metronidazole worked, they all just seemed to scratch their heads about it, shrug, and then launch into a discussion about biologics. So I'm wondering, has anyone else out there with IBD had this kind of experience with antibiotics?