Antifungals and Crohn's

[Pangolin]

Does anyone have any experience with antifungals on Crohn's? It seems like a somewhat promising area of research, but I don't think I've seen anything from any patients. I guess very few people have tried this out.

There's some evidence that Malassezia fungus may be involved in Crohn's. See this website: https://www.malassezia.org/i-love-details

There was a paper back in 2010 about some patients treated for histoplasmosis with itraconazole who apparently had some good results: https://onlinelibrary.wiley.com/doi/full/10.1111/j.1365-2036.2010.04444.x

And there are at least a couple of trials going on now testing out antifungals for Crohn's patients (specifically, oral posaconazole, itraconazole, and terbinafine in these trials)

Pilot Study of Posaconazole in Crohn's Disease - Full Text View - ClinicalTrials.gov

Pilot Study of Posaconazole in Crohn's Disease - Full Text View.

clinicaltrials.gov

Evaluation of the Response of Itraconazole and Terbinafine Therapy in Subjects With Crohn's Disease - Full Text View - ClinicalTrials.gov

Evaluation of the Response of Itraconazole and Terbinafine Therapy in Subjects With Crohn's Disease - Full Text View.

clinicaltrials.gov

 

[asadmom]

@Ignotius, do you have any insight on this?

 

[Ignotius]

my feelings are along the general assumptions we may have.....like....balance of biome and such, reaching to the opposite direction of leaky gut anythings etc...

but then we arrive to.......what causes the dysbiosis to begin with? type questions....

which still to me.....points to what we put in our mouths before other things....however, once chrons has developed it brings a life of its own to the party i dont think we can deny....we agree this is caused by different reasons and in particular what we are seeing with children these days alone proves that....

but then.....that takes me to how i came at rebuilding my biome after surgery....and imagining things like this, as a part of a something like that....but really i have no idea of course.....so, for me, what i did was sort of bomb certain cultures in periodically....rather than taking all of them constantly......by now i am sort of reduced to simpler type things, but i still feel i could/should be doing more....

i take a few supplements aimed at biome balance or killing baddies more specifically....aged garlic, quercetin, monolaurin.....pre/post-biotics over pro tho......i could imagine doing something like this just in terms of maintaining harmony if a fungal imbalance was detected, but i wonder also about side effects etc, if, it could be possible to achieve the same result with less risk...

we can actually consider this in terms of horticulture for a comparison.......if you over-innoculate a plant those "good" microbes will eat too much oxygen, which means the population booms, then starves as the bulk of it dies....which invites a boom of pathogenic strains which can COMPLETLY shift the balance to a point of death.....but we dont exactly want to attempt sterility in the interest of "optimum"....more likely balance.

depending where people are starting from, i could see some things like this as powerful tools....even as an initial "flush" type idea.....to get the baddies out to people new to all this and trying to deal with problems inside later than they wished, or ppl noticing odd reports in screenings etc...

then again, it could always be some mystery correlation that works in an indirect way right...

keeping researching,
regards

 

[asadmom]

Crohn's Trial | Malasseziafoundation

www.malasseziafoundation.org