I'm seeing my gastroenterologist this Wednesday to discuss where we go from here. I have failed Pentasa, Entocort, Humira, Imuran, and now Remicade (with the lupus-type reaction leading to surgery). I do well on prednisone, but every time I go off, I flare up. I see my options now as Cimzia, Tysabri, LDN, and maybe methotrexate. Can you guys think of any other drugs/treatments I may be forgetting? I'm sure there have to be others, and I want to be able to consider the risks/benefits of everything before deciding what to try next. I think the doctor is leaning towards Tysabri, but it just scares me to death. I would love to try the LDN, but I don't think I can stay off prednisone long enough to give it a try. Thanks for any input.