Thanks for the tag Clash, and sorry I haven't replied sooner. If you take it as nothing more than opinion from somebody else who has been in the same shoes as you, I would go for it. I've been on just about everything under the sun for crohns and methotrexate gave me the most benefits with the least side effects. First off though, make sure you get the injections and not the oral pills. I've done both and (like many others) got horrible side effects while taking the oral pills. As I'm sure you're aware, people experience different side effects due to different methods of administration.
While taking methotrexate orally, my doctor told me to take the medicine on Friday night or Saturday morning and warned me that there was a good chance I would feel like crap for a few days after and this way I would be home from work. He was right. For the 2 days after I literally spent the whole time on the couch and feeling like absolute crap... But at the time it was worth it because I needed medicine to help my crohns after other meds failed.
Because I had horrible side effects (although nothing serious) from the oral pills the doctor decided to switch me to the injections which would completely bypass the digestion period. I did the injections myself in the top of my leg and had very minor side effects. At first I got headaches for a few days after but that was fixed with tylenol. Some other side effects were fatigue and I also got the occasional night sweats.
I was never on Remicade and Methotrexate at the same time however and went to methotrexate because Remicade stopped working for me.