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Anyone taking Inflectra or another biosimilar? Your experiences?


Hello all -- looks like insurance denied Remicade, but Inflectra was listed as "preferred," so perhaps that's what I may be looking at. Waiting to hear. In the meantime, anyone here on Inflectra or another biosimilar? If so, what are your experiences on it?


Staff member
I actually started Inflectra yesterday, for the same reason: the NHS prefers to begin patients on biosimilars rather than the original-brand biologic now, for cost reasons. The literature indicates that there's no real difference between the original and the biosimilar in terms of effectiveness, which is fine by me!
After being on Remicade for four years, my symptoms were completely controlled for the past two years, and I was in complete remission. But my insurance wanted me to try the cheaper biosimilar, Renflexis. I was game and was really hoping it would work, due to the high price of Remicade. However, I flared and my symptoms returned with a vengeance, especially arthritis which hits me particularly hard. Given this, my doctor wrote a letter to the insurance company to get me back onto Remicade. The gastro symptons are much better now that I'm back on Remicade, but I still suffer from arthritis. I hope it gets better soon on Remicade, as it did last time. It just took a couple of years the first time around.

A couple of the nurses in the infusion center told me quietly that several other patients were experiencing the same thing.
I've been on Inflectra for just over a year now and it has helped to control my symptoms. Although I do have a few flare ups every so often so I have the infusions more frequently. Other than that it has been very good for me. I have more energy and I can do lots more activities than before I started Inflectra.


Thanks for the input y'all! I FINALLY got approval to start my infusions next week, so I'll let you know how it goes.

kiltubrid, this is interesting. I'm wondering if those patients experiencing the same thing were also started on Remicade, but then switched to a biosimilar and started experiencing problems. As a complete aside, I used to live in Madison for quite a while! Not sure how you're feeling at the moment, but if you're up to it, have an old fashioned and some cheese curds for me. ;)
I read a research paper a while back, albeit talking about Imuran, where the GI doc stated that whenever he starts patients on the brand, and moves them to the generic, they flare. Yet when he starts them on the generic, and then moves them to the brand, they remain well - and his recommendation was always to not take people off the brand name if they've already started.

I mean this makes no sense, as theoretically it should be the same drug, but that was his experience over a number of years.

(I'll update this post if I can find a link to the paper.)


Well, first Inflectra infusion went OK last week. Took some Tylenol and Claritin, and then had the infusion. The only two bad parts:

1. I now have a huge bruise on my forearm around the injection site -- doesn't really hurt much, but it isn't pretty.
2. Even though it's streaming, Netflix didn't allow me to download Black Panther to my device. So I couldn't watch it during my infusion. THANKS FOR NOTHING, NETFLIX.