When I first became sick, my upper right quadrant was the worst. I was getting chronic gastritis and had inflammation in my duodenum also -- may be why I had the higher pain. It used to actually get so bad that I'd have to take a Tylenol or sometimes a tramadol to be able to function. My doctor at the time prescribed carafate but for some reason that intensified the pain. I can sympathize... The higher up pain is really nauseating and annoying. I believe the Pentasa actually helped this as well like Tracy said.