Hi All, I am new to this forum and am in real need of advice at the moment. I was diagnosd with UC 15 years ago shortly after the birth of my first child. At the time I was very unwell but meds got it under control fairly quickly and I was in remission for a few years. I kept the UC at bay with Asacol suppositories. Although I had a few flare ups over the years the worst have been since being pregnant with my son in 2009, I have been on Mesalasine for the last few years along with the Asacol and it had kept it at bay, however since September 2012 I have been in my worst flare yet and even the Prednisolone cant get it under control. I am currently on 30mg Prednisolone, 100mg Azathioprine, 4800mg Mezavant and 2 Asacol a day with no releif. To top all this off I am now constipated, I am putting this down to the Azathioprine as I only started it a week ago. Has anyone else experienced constipation with AZA?????? and if so what did you do to go? usually I complain that I go too much and this is completely new and not pleasant. While i'm here I'd also like to know how those of you on Azathioprine felt in the first weeks as I am extremley tired and emotional (not sure if this is down to the Pred) Any advice is welcome. Thanks for reading. :ysmile: