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Bacteriophage therapy targeting adherent invasive ecoli

Background and Aims:
Adherent invasive Escherichia coli [AIEC] are abnormally predominant on the ileal mucosa of Crohn’s disease [CD] patients. They bind to the CEACAM6 receptor expressed on the surface of epithelial cells. We aimed to assess the potential of bacteriophages, viruses infecting bacteria, to decrease the levels of AIEC bacteria associated with the intestinal mucosa.

(They tested bacteriophages in mice and found they were effective at reducing certain strains of ecoli that may be associated with Crohn's)