I was diagnosed in 1994. did well on pentasa entocort 6mp for years. in 2009 my body stoped responding to meds. was put on remicade and had severe reaction. them was placed on methotrexate and humira. have had two surgeries to remove strictures and perforations. Now I have had to go on disability because scar tissue has destroyed my sphincter an cannot control bowels any longer. the injections are starting to take a toll on my body. After methotrexate injection I am unable to function for at least a day. The humira injection is causing severe nausa ang upper stomach pain. My doctors said these drugs are my last resort before I have to have to be placed on permanent ostomy. The doctors at duke said they may consider an intestinal transplant, I have never heard of this prceddure an found out it is experimental