Better time to stop Methotraxate

[ravii_39]

Hello I am a male in my 30’s and I am on methotraxate from past 1 year. How early we need to stop the medication when you are planning for a baby? My doctor suggested 3 months is enough but I would like to hear real experiences. Thanks

 

[my little penguin]

Methotrexate use in men attempting to father a child

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[my little penguin]

Is methotrexate safe for men with an immune-mediated inflammatory disease and an active desire to become a father? Results of a prospective cohort study (iFAME-MTX) | Annals of the Rheumatic Diseases

 

[my little penguin]

The toxicity of methotrexate in male fertility and paternal teratogenicity - PubMed

There is a high prevalence of methotrexate (MTX) use in males of reproductive age. The scope of this paper reviews what is known regarding risks to fertility and partners' pregnancy outcomes with regard to MTX use in men. Areas covered: This paper reviews the evidence for current recommendations...

pubmed.ncbi.nlm.nih.gov

Older paper 2017

 

[my little penguin]

Paternal methotrexate exposure affects sperm small RNA content and causes craniofacial defects in the offspring - Nature Communications

Anti-folate drugs, such as methotrexate, have been largely prohibited for pregnant women because of the teratogenic effect on their descendant. Here, the authors report a intergenerational mechanism by why paternal methotrexate exposure causes craniofacial defects on their offspring.

www.nature.com

 

[ravii_39]

Thanks @my little penguin