- Location
- Montréal, Canada
I would like to know of your experience with a Biologic agent (Remicade, Humira, Stelara, Vedo, etc) and rectal healing.
My disease always starts in the rectum and goes up in left colon and I am again in a debuting flare right now. I feel like I am done playing limbo with 6-mp. At 50mg it was keeping me in remission but it had to be reduced at 25mg/day for toxicity issues. relapse of disease. We tried 50mg twice a week as an increase with 5 days at 25mg, no success, flare again. Now my GI is suggesting 50mg / 6 days a week and 7th day off. Frankly I dont believe much the toxicity test will pass in a few months on that amount but its worth a try I guess. My GI really surprised me with this proposition. I am continuing the 5-asa rectal therapy as well even if I feel it does nothing for me.
My GI who I have great confidence in is an IBD specialist and wants to try everything possible with 6-mp before trying a biologic for me. He mentionned to me that rectal disease is sometimes refractory to biological therapy. ''I have observed some patients with pancolitis who have healed all colon with a Biologic but then the rectum remains in disease activity.'' I havent asked about what % of patients. I was sad to hear that. I have no other option left aside from Biologics if i fail again 6-mp. Methotrexate has failed for me. Switching from another big medication is already very scary to me and i am discouraged if on top of it it may fail to heal my rectum... I am building up a resistance to prenisone as well I notice with the last 2 flares, another thing that scared me Pred now takes 3 weeks to kick in and it used to be effective in a couple of days in my beautiful days...
Experience anyone with a Biologic and rectal disease activity?
thanks!
My disease always starts in the rectum and goes up in left colon and I am again in a debuting flare right now. I feel like I am done playing limbo with 6-mp. At 50mg it was keeping me in remission but it had to be reduced at 25mg/day for toxicity issues. relapse of disease. We tried 50mg twice a week as an increase with 5 days at 25mg, no success, flare again. Now my GI is suggesting 50mg / 6 days a week and 7th day off. Frankly I dont believe much the toxicity test will pass in a few months on that amount but its worth a try I guess. My GI really surprised me with this proposition. I am continuing the 5-asa rectal therapy as well even if I feel it does nothing for me.
My GI who I have great confidence in is an IBD specialist and wants to try everything possible with 6-mp before trying a biologic for me. He mentionned to me that rectal disease is sometimes refractory to biological therapy. ''I have observed some patients with pancolitis who have healed all colon with a Biologic but then the rectum remains in disease activity.'' I havent asked about what % of patients. I was sad to hear that. I have no other option left aside from Biologics if i fail again 6-mp. Methotrexate has failed for me. Switching from another big medication is already very scary to me and i am discouraged if on top of it it may fail to heal my rectum... I am building up a resistance to prenisone as well I notice with the last 2 flares, another thing that scared me Pred now takes 3 weeks to kick in and it used to be effective in a couple of days in my beautiful days...
Experience anyone with a Biologic and rectal disease activity?
thanks!
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