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Can my supervisor do this ?

Hi I am Charlotte . I work in a call centre and I am 4 months pregnant and have ibd. She has a new rule now that no one is allowed to go to the toilet unless it is their break time and we have to collect and sign for a key.
Do you live in the US? Have you made it known that you have a disability that requires you to have access to a restroom? If the answer to these is "yes", what she is doing is illegal. I would talk to her first. If that doesn't get anywhere, go to her supervisor.