Case Western: High Fat Diet Reduces Gut Bacteria, Crohn’s Disease Symptoms
Source:Researchers at Case Western Reserve University School of Medicine have shown a high fat diet may lead to specific changes in gut bacteria that could fight harmful inflammation—a major discovery for patients suffering from Crohn’s disease. Crohn’s disease, a type of inflammatory bowel syndrome, causes debilitating intestinal swelling, cramping, and diarrhea. The disease affects half a million people in the United States, but its cause is yet unclear.
In the new study, a diet of plant-derived “good” fats, including coconut oil or cocoa butter, drastically reduced bacterial diversity in mice with Crohn’s-like disease. Mice fed beneficial fatty diets had up to thirty percent fewer kinds of gut bacteria as those fed a normal diet, collectively resulting in a very different gut microbial composition. Some of the species changes showed up in feces, while others were different in cecum, a portion of the intestine commonly inflamed in Crohn’s disease. Mice fed even low concentrations of coconut oil or cocoa butter also had less severe small intestine inflammation.