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Cause of initial apthoid lesions

Is there an identified cause of the initial apthoid lesions found in Crohn's?

Or is the development of apthoid lesions within intestinal mucosa linked to the causes of disease itself - as in genetics, environment, infection, inappropriate immune response etc?

I'm currently writing a paper and am confused, considering the inflammatory response is said to occur AFTER apthoid lesion development, though what is causing these lesions in the first place?