I just had a colonoscopy without sedation as I prefer to participate in the procedure. It's not unbearably uncomfortable and it's actually VERY cool! Though my colon was very clean due to the bowel prep (worst part of the whole procedure!) there were lots of little white specks lining the colon. I asked the endoscopist & he said it was granules of Pentasa, even though I hadn't taken it for a day and had an otherwise sparkling clean bowel (I was sooo proud!). I'm not sure what it means, but it's interesting and relevant to this thread!