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Covid 19 -Vaccine - allergic reaction advisory

my little penguin

Staff member
UK warns people with serious allergies to avoid Pfizer vaccine after two adverse reactions
By Alistair Smout

LONDON (Reuters) - Britain’s medicine regulator has advised that people with a history of significant allergies do not get Pfizer-BioNTech’s COVID-19 vaccine after two people reported severe adverse reactions on the first day of rollout.

A member of staff prepares a phial of the Pfizer/BioNTech COVID-19 vaccine jab ahead of it being administered at a vaccination centre, on the first day of the largest immunisation programme in the British history, in Cardiff, Wales, Britain December 8, 2020. Ben Birchall/Pool via REUTERS
Starting with the elderly and frontline workers, Britain began mass vaccinating its population on Tuesday, part of a global drive that poses one of the biggest logistical challenges in peacetime history.
National Health Service medical director Stephen Powis said the advice had been changed after two NHS workers reported anaphylactoid reactions associated with receiving the vaccine.
“As is common with new vaccines the MHRA (regulator) have advised on a precautionary basis that people with a significant history of allergic reactions do not receive this vaccination, after two people with a history of significant allergic reactions responded adversely yesterday,” Powis said.
“Both are recovering well.”

The MHRA said it would seek further information, and Pfizer and BioNTech said they were supporting the MHRA’s investigation.
Last week Britain’s Medicines and Healthcare products Regulatory Agency (MHRA) became the first in the world to approve the vaccine, developed by Germany’s BioNTech and Pfizer, while the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) continue to assess the data.
“Last evening, we were looking at two case reports of allergic reactions. We know from the very extensive clinical trials that this wasn’t a feature,” MHRA Chief Executive June Raine told lawmakers.

Pfizer has said people with a history of severe adverse allergic reactions to vaccines or the candidate’s ingredients were excluded from their late stage trials, which is reflected in the MHRA’s emergency approval protocol.
The new MHRA guidance, sent out to health professionals, said a much broader segment should not take the vaccine.
“Any person with a history of a significant allergic reaction to a vaccine, medicine or food (such as previous history of anaphylactoid reaction or those who have been advised to carry an adrenaline autoinjector) should not receive the Pfizer BioNtech vaccine,” it said.
It also said resuscitation facilities should be available for all vaccinations.

In the United States, the FDA released documents on Tuesday in preparation for an advisory committee meeting on Thursday, saying the Pfizer vaccine’s efficacy and safety data met its expectations for authorization.
The briefing documents said 0.63% of people in the vaccine group and 0.51% in the placebo group reported possible allergic reactions in trials, which Peter Openshaw, Professor of Experimental Medicine at Imperial College London, said was a very small number.
“The fact that we know so soon about these two allergic reactions and that the regulator has acted on this to issue precautionary advice shows that this monitoring system is working well,” he said.
Reporting by Alistair Smout; additional reporting by Josephine Mason, Ludwig Burger and Patricia Weiss; Editing by Paul Sandle, Alexandra Hudson and Gareth Jones


Staff member
More about allergies and the COVID vaccine, from the NY Times:
Allergic reactions reported in two health workers who received a dose of Pfizer’s vaccine in Alaska this week have reignited concerns that people with a history of extreme immune flare-ups might not be good candidates for the newly cleared shots.

The two incidents follow another pair of cases in Britain. Three of the four were severe enough to qualify as anaphylaxis, a severe and potentially life-threatening reaction. But all four people appear to have recovered.
What does the F.D.A. say about these reactions?
Several experts raised concerns about the allergic reactions in meetings convened to discuss both Pfizer’s and Moderna’s vaccines. The agency has advised caution, noting that health care providers should not administer the vaccine to anyone with a “known history of a severe allergic reaction” to any component of the vaccine — a standard warning for vaccines.
Should people with mild allergies wait to get vaccinated?
There’s no evidence that people with mild allergies, which are quite common, need to avoid the vaccine. Allergies are, simply put, the product of an inappropriate immune response against something harmless — pollen, peanuts, cat dander and the like. In many cases, the results of this overreaction are mild symptoms such as a runny nose, coughing or sneezing.
But allergies are specific: A reaction to one substance does not guarantee a reaction to another. On Monday, the American College of Allergy, Asthma and Immunology released guidance stating that people with common allergies “are no more likely than the general public to have an allergic reaction to the Pfizer-BioNTech Covid-19 vaccine.”

William Amarquaye, a clinical pharmacist at Brandon Regional Hospital, said he wouldn’t let his asthma or allergies stop him from taking the vaccine when it is offered to him in the next few weeks. He’s also never had trouble with other vaccines he has taken in the past.
“It should still be OK to take the vaccine,” Dr. Amarquaye said. “I’m actually excited about it.”
What about people with a history of severe allergies?
Most people in this category should be good to go, too, said Dr. Eun-Hyung Lee, an expert in allergy and immunology at Emory University.
Guidelines released by the Centers for Disease Control and Prevention identify only one group of people who might not want to get Pfizer’s vaccine: those with a known history of severe allergic reactions to an ingredient in the injection.
People with a history of anaphylaxis to any other substance, including other vaccines or injectable drugs, can still get the vaccine, but should consult their health care providers and be monitored for 30 minutes after getting their shots. Everyone else, like people with mild or no allergies, need to wait only 15 minutes before leaving the vaccination site.
“In general, the immediate reactions that require epinephrine are those that happen within the first 30 minutes,” said Dr. Merin Kuruvilla, an allergist and immunologist at Emory University.
Some people will understandably be concerned. Dr. Taison Bell, a critical care physician at UVA Health in Charlottesville, Va., said he worried about his 7-year-old son, Alain, who is severely allergic to several foods, including wheat, peanuts and cow’s milk. Alain has about two bouts of anaphylaxis each year.
It’s a bit of a relief that Alain is “later in the prioritization schema,” Dr. Bell said. By the time a vaccine is ready for him, he said, “we’ll get a better sense for how serious this is.” The family plans to discuss their situation with Alain’s doctor.

Ultimately, it’s unlikely that any of the ingredients in a coronavirus vaccine would cause Alain any issues. Alain has tolerated other vaccines, including the flu shot, in previous years, and is looking forward to his own shot at immunization to the coronavirus, said Dr. Bell, who received his first dose of Pfizer’s vaccine on Tuesday.

my little penguin

Staff member
The thing to remember is most vaccines of ANY kind have a risk of allergic reaction which is why patients (kids infants Etc..) get a shot and wait at the doctors office afterwards .
4 people among the thousands abd thousands of vaccines already given in the past 2 weeks is a very small number .

If you have an allergic condition please discuss this with your doctor or your child’s doctor

Ds is highly allergic to things (food, pollens, animals ,drugs etc...)
So while he has had anaphylactic reactions to two different types of biologics and food . He should still be able to get the vaccine .

We are watching it closely by every single med he takes carries the risk of allergic reaction . The same with food unless I grow it in a garden in my backyard .

Remember risk vs benefit .
Every thing has a risk .

my little penguin

Staff member
Who Can Get the COVID-19 Vaccine?
Health care workers and people who live in long-term care facilities will get the vaccine first. As the supply grows, everyone will have a chance to get it. It will likely take a couple months before the general public can get the vaccine.

The following people can get the COVID-19 vaccine, with counseling from a doctor depending on the condition:

  • People ages 16 and older
  • People with medical conditions
  • People who are immunocompromised or immunosuppressed
  • Pregnant and lactating (nursing) people
  • People with allergies to food, pets, insects, venom, pollen, dust, latex, and oral medicines
  • People with a non-serious allergy to other vaccines or injectable medicines
  • People with a family history of anaphylaxis
Some people should talk to their doctor before getting the COVID-19 vaccine and should get the shots in a clinic or doctor’s office:

  • People with a moderate or acute (short-term) illness
  • People with a history of severe allergic reactions (anaphylaxis) to another vaccine or injectable medicine
People who are currently sick with COVID-19 should wait until they finish their self-isolation before getting the vaccine.



Staff member
Yes, exactly! From the article I posted earlier:

For anyone getting the vaccine, it’s all about “balancing out the risks,” Dr. Lee, of Emory, said. Allergic reactions can be dangerous. But they are rare and treatable, and the tools to combat them should be available at all vaccination sites. The coronavirus, on the other hand, can have far graver consequences.

“When it’s my turn in line, I think weighing these odds is what I would do,” Dr. Lee said.