Remicade put me into remission, and about 6 months in I developed severe joint pain and tested positive for antibodies. Switched to Humira, and about 4 months later the exact same joint pain came back, and yup... antibodies again! The frustrating part is that the Humira antibodies were discovered after I got pregnant I am excited about being pregnant as it was planned, but now I am on nothing. My doctor is afraid to try Cimzia without pairing it with Imuran to prevent antibody formation again, and obviously I can't be on Imuran while pregnant. Entyvio is also something he's considering, which would be after the baby is born. In the mean time, I'm almost 12 weeks pregnant so if I had to start prednisone I can, and I do think my Crohn's is starting to flare. Argghhh. The good news is, the TNF drugs did work for me.... my body just decided to reject them! Has this happened to anybody else?