Thank you for your responses!
I have already done Remicade - approx. 30 treatments between 2002 and 2009. Got pregnant and was in remission, so went off. Was able to stay drug feel until late last year, and decided to try Remicade again, but on my second infusion had a (minor) reaction - chest tightening and flushing, which went away when the drug was turned off. I was already pre-medicated with steroids and benadryl. Tried one more, and same thing, so had to quit. It wasn't working as well as it used to anyway.
Humira was next - started end March 2013. Like I mentioned above, responded well to loading doses, but symptoms back with fortnightly, and now weekly as well. I maybe got one-two days of slight improvement this week.
Gra - I have excellent insurance and they are covering weekly and would cover twice weekly as well.
I will do some more digging to see about side effects and antibodies on higher doses.
Thanks again for your responses. Go see my GI next week. They have mentioned Simponi as a possible next step as well. I am in a town with a university so they are often running clinical trials.