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Edema, Neuropathy anyone?

Has anyone experienced ankle edema? I have never had it in my life now shortly after my 3rd infusion my socks are leaving deep marks on my skin. I also have neuropathy in my right foot - started after 2nd infusion. B-12 low normal so tried shots and it helped a little but over a month after sky high B-12 levels attained I still have some numbness. GI doc also thinks I'm crazy and that it isn't related but I lived 48 years without any of this and it suddenly starts when I begin Remicade. All lab work looks perfect - nothing points to anything wrong with me on CBC, Metabolic Panel and Amylase/Lipase.
This is slightly different but may fall into the same category. A few years ago, I noticed a rash on my lower leg and it was a little inflamed and red. My GP was sure is was from Crohns. I've had Crohns since I was 6 and this was the first time I'd seen anything like this in almost 40 years. It went away on its own although it took a month or two.